Pax6 - paired box 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25509

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including cellular response to hormone stimulus; enteroendocrine cell differentiation; and nervous system development. Located in chromatin and nucleus. Used to study autistic disorder. Biomarker of Smith-Lemli-Opitz syndrome and transient cerebral ischemia. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Apr 2022]

Pax6 Products (1)

mRNA Protein Name
NM_013001.2 NP_037133.1 paired box protein Pax-6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20592023 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20592023 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
12370174 RGD
enables minor groove of adenine-thymine-rich DNA binding IDA
IDA: Inferred from direct assay
12370174 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12370174 RGD
Biological Process GO Annotation Evidence References Source
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22944581 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
18189319 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
21818840 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
18189319 RGD
involved in cellular response to prostaglandin E stimulus IEP
IEP: Inferred from expression pattern
23257891 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19619535 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
11688562 RGD
involved in epithelial cell development IMP
IMP: Inferred from mutant phenotype
19393751 RGD
involved in hindbrain development IDA
IDA: Inferred from direct assay
11880342 RGD
involved in hindbrain development IMP
IMP: Inferred from mutant phenotype
20082710 RGD
involved in insulin metabolic process IMP
IMP: Inferred from mutant phenotype
21069736 RGD
involved in interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
17825043 RGD
involved in learned vocalization behavior or vocal learning IMP
IMP: Inferred from mutant phenotype
21203536 RGD
involved in neural crest cell migration IMP
IMP: Inferred from mutant phenotype
9079035 RGD
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
22944581 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
12534968 RGD
involved in olfactory bulb development IMP
IMP: Inferred from mutant phenotype
14736749 RGD
involved in olfactory bulb mitral cell layer development IMP
IMP: Inferred from mutant phenotype
14736749 RGD
involved in pancreatic A cell development IMP
IMP: Inferred from mutant phenotype
20592023 RGD
involved in pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
20592023 RGD
involved in positive regulation of cell fate specification IMP
IMP: Inferred from mutant phenotype
11880342 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11222774 RGD
involved in positive regulation of glutamatergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
24030726 RGD
involved in positive regulation of neuron migration IGI
IGI: Inferred from genetic interaction
11688562 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20592023 RGD
involved in regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16164600 RGD
involved in regulation of neuron differentiation IDA
IDA: Inferred from direct assay
11880342 RGD
involved in regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
11688562 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
21073715 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
19012751 RGD
involved in rhombomere morphogenesis IMP
IMP: Inferred from mutant phenotype
21501682 RGD
involved in sensory neuron migration IMP
IMP: Inferred from mutant phenotype
16510508 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
20195794 RGD
involved in type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
22403172 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20592023 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired box protein Pax-6

  • oculorhombin

  • paired box gene 6

  • paired box homeotic gene 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10093 PAX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174557 Human PAX6 mRNA / Unkown
HY-RS20319 Pax6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26827 Pax6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pax6 NCBI NCBI:5080