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Prkcz - protein kinase C, zeta Gene

Also Known as Pkcz; r14-3-3; 14-3-3-zetaisoform

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25522

About Prkcz

Primary_assembly 5: 165,819,466-165,930,367 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 205 orthologues, 9 paralogues and is associated with 23 phenotypes. Biased expression in Brain (RPKM 18.1), Kidney (RPKM 59.9) and 7 other tissues.

Summary

Enables several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of Phospholipase D activity; activation of protein kinase B activity; and positive regulation of cell communication. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz Products (1)

mRNA	Protein	Name
NM_022507.1	NP_071952.1	protein kinase C zeta type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	17308302	RGD
enables phospholipase binding	IPI IPI: Inferred from physical interaction	16113073	RGD
enables potassium channel regulator activity	IMP IMP: Inferred from mutant phenotype	15062979	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9514928	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	9768361	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12130632	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10477520	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in activation of phospholipase D activity	IMP IMP: Inferred from mutant phenotype	16113073	RGD
involved in activation of protein kinase B activity	IMP IMP: Inferred from mutant phenotype	15007074	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19885391	RGD
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15007074	RGD
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	16525020	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	11525734	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12130632	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	17702943	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	11914719	RGD
involved in membrane depolarization	IMP IMP: Inferred from mutant phenotype	15381257	RGD
involved in membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	15062979	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17346242	RGD
involved in negative regulation of hydrolase activity	IDA IDA: Inferred from direct assay	17346242	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12061804	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	8557035	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	8557035	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16679391	RGD
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	16113073	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	11914719	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9374484	RGD
involved in positive regulation of protein transport	IMP IMP: Inferred from mutant phenotype	15007074	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15728837	RGD
involved in protein kinase C signaling	IMP IMP: Inferred from mutant phenotype	20570724	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10477520	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	18667614	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	18667614	RGD
involved in vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	16734659	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18667614	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18667614	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	19885391	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18667614	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18667614	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16525020	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11525734	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	24298142	RGD
located in stress fiber	IDA IDA: Inferred from direct assay	16525020	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcz Protein Structure

PB1_aPKC

C1_aPKC_zeta

STKc_aPKC_zeta

0
100
200
300
400
500
605 a.a.

Protein Preferred Names	Protein Names
protein kinase C zeta type	nPKC-zeta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11141	PRKCZ Human Pre-designed siRNA Set A		/	Unkown
HY-RS11142	Prkcz Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11143	Prkcz Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcz	NCBI	NCBI:5590