SLC2A3 - solute carrier family 2 member 3 Gene

Also Known as GLUT3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25551

About SLC2A3

Primary_assembly 4: 155,960,946-156,025,472 reverse strand.mRatBN7.2:CM026977.1

This gene has 3 transcripts (splice variants), 254 orthologues, 12 paralogues and is associated with 20 phenotypes. Biased expression in Testes (RPKM 617.3), Brain (RPKM 246.8) and 6 other tissues.

Summary

Enables several functions, including dehydroascorbic acid transmembrane transporter activity; galactoside binding activity; and monosaccharide binding activity. Involved in several processes, including dehydroascorbic acid transport; glucose import; and response to Thyroglobulin triiodothyronine. Located in caveola and synaptic vesicle membrane. Is active in glutamatergic synapse. Is integral component of synaptic membrane. Biomarker of cataract and hypertension. Orthologous to human SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Apr 2022]

SLC2A3 Products (2)

mRNA Protein Name
NM_017102.3 NP_058798.2 solute carrier family 2, facilitated glucose transporter member 3 isoform 1
NM_001412552.1 NP_001399481.1 solute carrier family 2, facilitated glucose transporter member 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose binding IDA
IDA: Inferred from direct assay
8645164 RGD
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
15320870 RGD
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
18668520 RGD
enables galactoside binding IDA
IDA: Inferred from direct assay
8645164 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
16419038 RGD
enables monosaccharide transmembrane transporter activity IDA
IDA: Inferred from direct assay
8645164 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16419038 RGD
enables xylose binding IDA
IDA: Inferred from direct assay
8645164 RGD
Biological Process GO Annotation Evidence References Source
involved in D-glucose import IDA
IDA: Inferred from direct assay
15320870 RGD
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
18668520 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
16581179 RGD
involved in dehydroascorbic acid transport IDA
IDA: Inferred from direct assay
18668520 RGD
involved in monosaccharide transmembrane transport IDA
IDA: Inferred from direct assay
8645164 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15320870 RGD
involved in response to Thyroglobulin triiodothyronine IEP
IEP: Inferred from expression pattern
16581179 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12882795 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
16419038 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
18668520 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21307237 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18668520 RGD
is active in synaptic membrane IDA
IDA: Inferred from direct assay
21307237 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
10318820 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A3 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (13 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 3

  • GLUT-3

  • Solute carrier family 2 A3 (neuron glucose transporter)

  • glucose transporter type 3, brain

  • solute carrier family 2 (facilitated glucose transporter), member 3

  • solute carrier family 2, facilitated glucose transporter member 3-like

  • solute carrier family 2, member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13167 SLC2A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13168 Slc2a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13169 SLC2A3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SLC2A3 NCBI NCBI:6515