Slc6a4 - solute carrier family 6 member 4 Gene

Also Known as SERT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25553

About Slc6a4

Primary_assembly 10: 61,826,123-61,858,384 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 205 orthologues, 20 paralogues and is associated with 54 phenotypes. Biased expression in Lung (RPKM 17.1), Adrenal (RPKM 71.6) and 4 other tissues.

Summary

Enables several functions, including cocaine binding activity; serotonin:sodium symporter activity; and syntaxin-1 binding activity. Involved in several processes, including cellular response to cGMP; cellular response to retinoic acid; and negative regulation of dopaminergic synaptic transmission. Located in several cellular components, including membrane raft; neuron projection; and synapse. Is active in serotonergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study anxiety disorder; mental depression; and pulmonary hypertension. Biomarker of Parkinsonism and borna disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a4 Products (1)

mRNA Protein Name
NM_013034.4 NP_037166.2 sodium-dependent serotonin transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
15627510 RGD
enables cocaine binding IMP
IMP: Inferred from mutant phenotype
15994310 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10716733 RGD
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
8968583 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16870614 RGD
enables serotonin:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
1944572 RGD
enables serotonin:sodium:chloride symporter activity IMP
IMP: Inferred from mutant phenotype
8601815 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
11709063 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
18581099 RGD
involved in cellular response to cGMP IDA
IDA: Inferred from direct assay
17310063 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
17895527 RGD
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
18482738 RGD
involved in conditioned place preference IMP
IMP: Inferred from mutant phenotype
18581099 RGD
involved in male mating behavior IMP
IMP: Inferred from mutant phenotype
20704641 RGD
involved in membrane depolarization IDA
IDA: Inferred from direct assay
14642278 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
20730799 RGD
involved in negative regulation of cerebellar granule cell precursor proliferation IMP
IMP: Inferred from mutant phenotype
18573488 RGD
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18573488 RGD
involved in negative regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
20730799 RGD
involved in positive regulation of serotonin secretion IMP
IMP: Inferred from mutant phenotype
25261262 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19168037 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
11259539 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
21068163 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20501324 RGD
involved in serotonin transport IDA
IDA: Inferred from direct assay
11709063 RGD
involved in serotonin transport IMP
IMP: Inferred from mutant phenotype
15994310 RGD
involved in serotonin uptake IDA
IDA: Inferred from direct assay
10716733 RGD
involved in vasoconstriction IMP
IMP: Inferred from mutant phenotype
14605793 RGD
Cellular Component GO Annotation Evidence References Source
located in endomembrane system IDA
IDA: Inferred from direct assay
16870614 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
8601815 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
10460242 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
10460242 RGD
is active in serotonergic synapse IDA
IDA: Inferred from direct assay
10460242 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a4 Protein Structure

5HT_transport_N

5HT_transport_N: pfam03491 (23 - 63)

SLC6sbd_SERT

SLC6sbd_SERT: cd11513 (78 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 630 a.a.
Protein Preferred Names Protein Names

sodium-dependent serotonin transporter

  • 5HT transporter

  • 5HTT

  • Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)

  • serotonin transporter

  • solute carrier family 6 (neurotransmitter transporter), member 4

  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110023R Zimelidine dihydrochloride (Standard) Inhibitor / Unkown
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13313 Slc6a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a4 NCBI NCBI:6532