Alpl - alkaline phosphatase, biomineralization associated Gene

Also Known as Akp2; PHOA; TNAP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25586

Summary

Enables Alkaline Phosphatase activity. Involved in cementum mineralization; response to glucocorticoid; and response to lipopolysaccharide. Located in extracellular space and plasma membrane. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (Alkaline Phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Apr 2022]

Alpl Products (1)

mRNA Protein Name
NM_013059.2 NP_037191.2 alkaline phosphatase, tissue-nonspecific isozyme precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alkaline phosphatase activity IDA
IDA: Inferred from direct assay
3472490 RGD
Biological Process GO Annotation Evidence References Source
involved in cementum mineralization IEP
IEP: Inferred from expression pattern
17043865 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
2039500 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11810315 RGD
involved in response to macrophage colony-stimulating factor IEP
IEP: Inferred from expression pattern
7669437 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
Cellular Component GO Annotation Evidence References Source
is active in extracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
32710882 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19697513 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alkaline phosphatase, tissue-nonspecific isozyme

  • AP-TNAP

  • TNSALP

  • Tissue-nonspecific ALP alkaline phosphatase

  • alkaline phosphatase 2, liver

  • alkaline phosphatase liver/bone/kidney isozyme

  • alkaline phosphatase, liver/bone/kidney

  • phosphoamidase

  • phosphocreatine phosphatase

  • tissue-nonspecific alkaline

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-RS00632 ALPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17484 Alpl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23942 Alpl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alpl NCBI NCBI:249