Pcmt1 - protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Gene

Also Known as PCM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25604

Summary

Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; negative regulation of cardiac muscle cell apoptotic process; and response to ethanol. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Biomarker of high grade glioma. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Pcmt1 Products (3)

mRNA Protein Name
NM_001398561.1 NP_001385490.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform a
NM_001398562.1 NP_001385491.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform c
NM_013073.4 NP_037205.3 protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S-adenosylmethionine-dependent methyltransferase activity IDA
IDA: Inferred from direct assay
8263531 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23647599 RGD
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
IDA: Inferred from direct assay
8263531 RGD
Biological Process GO Annotation Evidence References Source
involved in S-adenosylhomocysteine metabolic process IDA
IDA: Inferred from direct assay
8263531 RGD
involved in S-adenosylmethionine metabolic process IDA
IDA: Inferred from direct assay
8263531 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
23647599 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23647599 RGD
involved in protein methylation IDA
IDA: Inferred from direct assay
1886138 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17336420 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
7639720 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
7639720 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9188065 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
7783974 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-L-isoaspartate(D-aspartate) O-methyltransferase

  • L-isoaspartyl protein carboxyl methyltransferase

  • PIMT

  • protein L-isoaspartyl/D-aspartyl methyltransferase

  • protein-beta-aspartate methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10157 PCMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21683 Pcmt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28201 Pcmt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcmt1 NCBI NCBI:5110