Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Also Known as MCR; Mlr

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25672

About Nr3c2

Primary_assembly 19: 30,715,648-31,059,885 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 11 phenotypes. Biased expression in Kidney (RPKM 16.1), Heart (RPKM 15.8) and 9 other tissues.

Summary

Enables several functions, including DNA binding activity; identical protein binding activity; and steroid hormone receptor activity. Involved in regulation of cell population proliferation. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 Products (2)

mRNA	Protein	Name
NM_013131.2	NP_037263.2	mineralocorticoid receptor
NM_001395077.1	NP_001382006.1	mineralocorticoid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	8618925	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	10847590	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8618925	RGD
enables nuclear steroid receptor activity	IMP IMP: Inferred from mutant phenotype	17260968	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12902338	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables steroid binding	IMP IMP: Inferred from mutant phenotype	17260968	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	10847590	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to aldosterone	IEP IEP: Inferred from expression pattern	16087789	RGD
involved in cellular response to aldosterone	IMP IMP: Inferred from mutant phenotype	10847590	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	30171933	RGD
involved in nuclear receptor-mediated corticosteroid signaling pathway	IDA IDA: Inferred from direct assay	10399770	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10847590	RGD
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16115202	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	16925589	RGD
involved in response to corticosterone	IDA IDA: Inferred from direct assay	10399770	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16087789	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21179518	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16087789	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	21179518	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	21179518	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c2 Protein Structure

NR_DBD_GR_PR

NR_LBD_MR

0
200
400
600
800
985 a.a.

Protein Preferred Names	Protein Names
mineralocorticoid receptor	MR Mineralocorticoid receptor (aldosterone receptor)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09547	NR3C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09548	Nr3c2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09549	Nr3c2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr3c2	NCBI	NCBI:4306