Cpt1a - carnitine palmitoyltransferase 1A Gene

Also Known as CPT-Ia

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25757

Summary

Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Biomarker of alcoholic hepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Cpt1a Products (1)

mRNA Protein Name
NM_031559.2 NP_113747.2 carnitine O-palmitoyltransferase 1, liver isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carnitine O-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
11790778 RGD
enables carnitine O-palmitoyltransferase activity IMP
IMP: Inferred from mutant phenotype
9169604 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19136561 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19429947 RGD
Biological Process GO Annotation Evidence References Source
involved in aflatoxin metabolic process IEP
IEP: Inferred from expression pattern
28959666 RGD
involved in carnitine metabolic process IDA
IDA: Inferred from direct assay
21990363 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19332540 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
12754501 RGD
involved in fatty acid beta-oxidation IEP
IEP: Inferred from expression pattern
31901136 RGD
involved in fatty acid metabolic process IDA
IDA: Inferred from direct assay
24222496 RGD
involved in fatty acid metabolic process IEP
IEP: Inferred from expression pattern
30851372 RGD
involved in glucose metabolic process IMP
IMP: Inferred from mutant phenotype
12754501 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
31953200 RGD
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
21990363 RGD
involved in long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
19302064 RGD
involved in positive regulation of fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
19302064 RGD
involved in regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
11988095 RGD
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
11988095 RGD
involved in regulation of lipid storage IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
30868489 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
30851372 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16751799 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
31918260 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19553925 RGD
involved in triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
18349115 RGD
Cellular Component GO Annotation Evidence References Source
NOT located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12401113 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
9169604 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carnitine O-palmitoyltransferase 1, liver isoform

  • CPT I

  • CPT1-L

  • CPTI-L

  • carnitine palmitoyltransferase 1, liver

  • carnitine palmitoyltransferase 1a, liver

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-115938 BEC2 Activator 98.0% Phase 3
HY-168046 ALG-055009 Agonist 95.32% Phase 2

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50202 Etomoxir 99.58% Yes
HY-12364 C75 99.91% Unkown
HY-50202A Etomoxir sodium salt 99.79% Yes
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-N0723 Neomangiferin 99.80% Unkown
HY-50670 DGAT-1 inhibitor 2 95.33% Unkown
HY-RS03122 CPT1A Human Pre-designed siRNA Set A / Unkown
HY-W588256 12-Tridecenoic acid Activator 95.0% Unkown
HY-W420033 (S)-(+)-Etomoxir 98.65% Unkown
HY-161027 2,6-Didehydropeperomin B / Unkown
HY-N8144 Niga-ichigoside F1 99.0% Unkown
HY-N9333 Wistin Agonist 97.63% Unkown
HY-50202R Etomoxir (Standard) 99.56% Unkown
HY-RS16248 Cpt1a Mouse Pre-designed siRNA Set A / Unkown
HY-12364B (−)-C75 / Unkown
HY-183318 PPARα/δ agonist 4 Agonist / Unkown
HY-116257 GSK-7227 Agonist 98.03% Unkown
HY-RS23138 Cpt1a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpt1a NCBI NCBI:1374