LRIG1 - leucine rich repeats and immunoglobulin like domains 1 Gene

Homo sapiens

Also known as LIG1; LIG-1

Gene ID: 26018 | Gene type: protein coding

About LRIG1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:66,378,797-66,501,121 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 61.1), fat (RPKM 28.0) and 23 other tissues.

Summary

Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRIG1 Products(7)

mRNA	Protein	Name
NM_001377344.1	NP_001364273.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor
NM_001377345.1	NP_001364274.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377346.1	NP_001364275.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377347.1	NP_001364276.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 4
NM_001377348.1	NP_001364277.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 5
NM_001377349.1	NP_001364278.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 6
NM_015541.3	NP_056356.2	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

LRIG1 Protein Structure

LRR_8

LRRCT

I-set

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 1

leucine-rich repeat protein LRIG1

Recombinant LRIG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77988	LRIG1 Protein, Human (HEK293, His)	Q96JA1 (A35-S779)	≥95%

Related Diseases

Diseases

Alias

Urofacial Syndrome 1

Urofacial Syndrome	Ochoa Syndrome
Hydronephrosis With Peculiar Facial Expression	Ufs
Inverted Smile And Occult Neuropathic Bladder	Partial Facial Palsy With Urinary Abnormalities
UFS1	Urofacial Ochoa'S Syndrome
Urofacial Syndrome Type 1	Facial Palsy, Partial, With Urinary Abnormalities
Hydronephrosis-Inverted Smile	Inverted Smile-Neurogenic Bladder
Hydronephrosis-Inverted Smile Syndrome	Inverted Smile-Neurogenic Bladder Syndrome
Partial Facial Palsy Partial With Urinary Abnormalities	Urologic Diseases

Sebaceous Adenoma

Adenoma Of The Sebaceous Gland

Skin Appendage Sebaceous Adenoma

Sebaceous Gland Neoplasm

Sebaceous Gland Neoplasms

Sebaceous Neoplasm

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07787	LRIG1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRIG1	RGD	RGD:1306788
Macaca mulatta	LRIG1	VGNC	VGNC:84156
Canis familiaris	LRIG1	VGNC	VGNC:42767
Bos taurus	LRIG1	VGNC	VGNC:30982
Felis catus	LRIG1	VGNC	VGNC:80612
Mus musculus	LRIG1	MGD	MGI:107935
Macaca fascicularis	LRIG1	NCBI
Others	LRIG1	NCBI

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