CYP4X1 - cytochrome P450 family 4 subfamily X member 1 Gene

Also Known as CYPIVX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 260293

About CYP4X1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,961,364-47,055,432 (from NCBI)

This gene has 2 transcripts (splice variants), 397 orthologues and 12 paralogues. Broad expression in prostate (RPKM 4.4), lung (RPKM 4.1) and 23 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CYP4X1 Products (3)

mRNA	Protein	Name
NM_001320289.2	NP_001307218.1	cytochrome P450 4X1 isoform 2
NM_001320290.2	NP_001307219.1	cytochrome P450 4X1 isoform 3
NM_178033.2	NP_828847.1	cytochrome P450 4X1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables anandamide 14,15 epoxidase activity	IDA IDA: Inferred from direct assay	18549450	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4X1 Protein Structure

p450

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 4X1	cytochrome P450, family 4, subfamily X, polypeptide 1

Related Diseases

Diseases	Alias
Bietti Crystalline Corneoretinal Dystrophy	BCD Bietti Crystalline Dystrophy Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy Bietti Crystalline Retinopathy Bietti'S Crystalline Dystrophy Crystalline Retinopathy Dystrophy, Corneoretinal, Crystalline, Bietti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03484	CYP4X1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CYP4X1	VGNC	VGNC:103325
Macaca mulatta	CYP4X1	VGNC	VGNC:103614
Canis familiaris	CYP4X1	VGNC	VGNC:50372
Mus musculus	CYP4X1	MGD	MGI:1932403
Rattus norvegicus	CYP4X1	RGD	RGD:628719