STEAP2 - STEAP2 metalloreductase Gene

Also Known as STMP; IPCA1; PUMPCn; STAMP1; PCANAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 261729

About STEAP2

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,211,740-90,243,408 (from NCBI)

This gene has 10 transcripts (splice variants), 195 orthologues and 4 paralogues. Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues.

Summary

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate Cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

STEAP2 Products (6)

mRNA Protein Name
NM_001040665.2 NP_001035755.1 metalloreductase STEAP2 isoform a
NM_001040666.2 NP_001035756.1 metalloreductase STEAP2 isoform b
NM_001244944.2 NP_001231873.1 metalloreductase STEAP2 isoform a
NM_001244945.2 NP_001231874.1 metalloreductase STEAP2 isoform b
NM_001244946.2 NP_001231875.1 metalloreductase STEAP2 isoform c
NM_152999.4 NP_694544.2 metalloreductase STEAP2 isoform a

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in Golgi to plasma membrane transport IDA
IDA: Inferred from direct assay
12095985 GOA
involved in endocytosis IDA
IDA: Inferred from direct assay
12095985 GOA
involved in regulated exocytosis IDA
IDA: Inferred from direct assay
12095985 GOA
involved in response to hormone IDA
IDA: Inferred from direct assay
12095985 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
12095985 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12095985 GOA
located in early endosome IDA
IDA: Inferred from direct assay
12095985 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12095985 GOA
located in trans-Golgi network transport vesicle IDA
IDA: Inferred from direct assay
12095985 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STEAP2 Protein Structure

F420_oxidored

F420_oxidored: NADP oxidoreductase coenzyme F420-dependent (32 - 118)

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (259 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

metalloreductase STEAP2

  • STEAP family member 2, metalloreductase

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 11

  • Hypertrophic Cardiomyopathy 11

  • CMH11

  • Cardiomyopathy, Hypertrophic, 11

  • Cardiomyopathy Familial Hypertrophic 11

  • Cardiomyopathy, Familial Hypertrophic 11

  • Cardiomyopathy, Hypertrophic, Familial, Type 11
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Aceruloplasminemia

  • Cerebellar Ataxia

  • Hypoceruloplasminemia

  • Hemosiderosis, Systemic, Due To Aceruloplasminemia

  • Familial Apoceruloplasmin Deficiency

  • Hereditary Ceruloplasmin Deficiency

  • Deficiency Of Ferroxidase

  • Hypoceruloplasminemia, Hereditary

  • Ceruloplasmin Deficiency

  • Systemic Hemosiderosis Due To Aceruloplasminemia

  • ACERULOP
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-173639 AZD0516 99.15% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13907 STEAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21200 Steap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27716 Steap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991503 Anti-STEAP2 Antibody 99.65% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STEAP2 VGNC VGNC:46897
Bos taurus STEAP2 VGNC VGNC:35379
Mus musculus STEAP2 MGD MGI:1921301
Macaca mulatta STEAP2 VGNC VGNC:77946
Rattus norvegicus STEAP2 RGD RGD:1307050
Felis catus STEAP2 VGNC VGNC:65768
Others STEAP2 NCBI