STEAP2 - STEAP2 metalloreductase Gene

Homo sapiens

Also known as STMP; IPCA1; PUMPCn; STAMP1; PCANAP1

Gene ID: 261729 | Gene type: protein coding

About STEAP2

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,211,740-90,243,408 (from NCBI)

This gene has 10 transcripts (splice variants), 195 orthologues and 4 paralogues. Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues.

Summary

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate Cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

STEAP2 Products(6)

mRNA	Protein	Name
NM_001040665.2	NP_001035755.1	metalloreductase STEAP2 isoform a
NM_001040666.2	NP_001035756.1	metalloreductase STEAP2 isoform b
NM_001244944.2	NP_001231873.1	metalloreductase STEAP2 isoform a
NM_001244945.2	NP_001231874.1	metalloreductase STEAP2 isoform b
NM_001244946.2	NP_001231875.1	metalloreductase STEAP2 isoform c
NM_152999.4	NP_694544.2	metalloreductase STEAP2 isoform a

STEAP2 Protein Structure

F420_oxidored

Ferric_reduct

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

metalloreductase STEAP2

STEAP family member 2, metalloreductase

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 11

Hypertrophic Cardiomyopathy 11	CMH11
Cardiomyopathy, Hypertrophic, 11	Cardiomyopathy Familial Hypertrophic 11
Cardiomyopathy, Familial Hypertrophic 11	Cardiomyopathy, Hypertrophic, Familial, Type 11

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13907	STEAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STEAP2	VGNC	VGNC:46897
Bos taurus	STEAP2	VGNC	VGNC:35379
Mus musculus	STEAP2	MGD	MGI:1921301
Macaca mulatta	STEAP2	VGNC	VGNC:77946
Rattus norvegicus	STEAP2	RGD	RGD:1307050
Felis catus	STEAP2	VGNC	VGNC:65768

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