PLA2G2D - phospholipase A2 group IID Gene

Also Known as SPLASH; sPLA2S; PLA2IID; sPLA2-IID

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26279

About PLA2G2D

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,111,939-20,119,536 (from NCBI)

This gene has 2 transcripts (splice variants), 118 orthologues and 8 paralogues. Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues.

Summary

This gene encodes a secreted member of the Phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

PLA2G2D Products (2)

mRNA Protein Name
NM_001271814.2 NP_001258743.1 group IID secretory phospholipase A2 isoform 2 precursor
NM_012400.4 NP_036532.1 group IID secretory phospholipase A2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
10681567 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylcholine metabolic process IDA
IDA: Inferred from direct assay
10681567 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G2D Protein Structure

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (22 - 130)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

group IID secretory phospholipase A2

  • GIID sPLA2

Recombinant PLA2G2D Proteins

Cat. No. Product Name Accession Purity
HY-P71653 PLA2G2D Protein, Human (His-SUMO) Q9UNK4 (I22-C145) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gas Gangrene

  • Myonecrosis

  • Gas Bacillus Infection

  • Gas Gangrene Due To Clostridia

  • Clostridial Myonecrosis

  • Clostridial Cellulitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10622 PLA2G2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18576 Pla2g2d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25060 Pla2g2d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G2D RGD RGD:1309862
Canis familiaris PLA2G2D VGNC VGNC:44623
Felis catus PLA2G2D VGNC VGNC:107601
Macaca mulatta PLA2G2D VGNC VGNC:100038
Mus musculus PLA2G2D MGD MGI:1341796
Others PLA2G2D NCBI