Esrrb - estrogen related receptor, beta Gene

Also Known as Err2; Errb; Nr3b2; Estrrb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26380

About Esrrb

Chromosome 12: 86,407,891-86,568,402 forward strand.GRCm39:CM001005.3

This gene has 6 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 15 phenotypes. Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Esrrb Products (2)

mRNA Protein Name
NM_001159500.1 NP_001152972.1 steroid hormone receptor ERR2 isoform 2
NM_011934.4 NP_036064.3 steroid hormone receptor ERR2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18957414 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18662995 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
27723719 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18662995 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
27723719 MGI
enables RNA polymerase II complex binding IDA
IDA: Inferred from direct assay
23019124 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18662995 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23508100 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18509053 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23169531 MGI
Biological Process GO Annotation Evidence References Source
involved in cell dedifferentiation IDA
IDA: Inferred from direct assay
23040477 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
9285590 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9285590 MGI
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
17765677 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18957414 MGI
involved in negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
26206133 MGI
involved in photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
20534447 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20534447 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23019124 MGI
involved in positive regulation of glycogen biosynthetic process IDA
IDA: Inferred from direct assay
24481529 MGI
involved in positive regulation of stem cell population maintenance IDA
IDA: Inferred from direct assay
23040477 MGI
involved in positive regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
23019124 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22977234 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18662995 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27723719 MGI
involved in regulation of stem cell division IDA
IDA: Inferred from direct assay
23040477 MGI
involved in regulation of stem cell division IMP
IMP: Inferred from mutant phenotype
23019124 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
16518401 MGI
involved in stem cell division IMP
IMP: Inferred from mutant phenotype
23040478 MGI
involved in stem cell population maintenance IDA
IDA: Inferred from direct assay
18957414 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
23169531 MGI
acts upstream of or within trophectodermal cell proliferation IMP
IMP: Inferred from mutant phenotype
9285590 MGI
acts upstream of or within trophectodermal cellular morphogenesis IMP
IMP: Inferred from mutant phenotype
9285590 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome IMP
IMP: Inferred from mutant phenotype
27723719 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18472334 MGI
part of integrator complex IDA
IDA: Inferred from direct assay
26206133 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18472334 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrrb Protein Structure

NR_DBD_ERR

NR_DBD_ERR: cd07170 (118 - 213)

NR_LBD_ERR

NR_LBD_ERR: cd06946 (232 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

steroid hormone receptor ERR2

  • ERR-beta

  • estrogen receptor related 2

  • estrogen receptor-like 2

  • nuclear receptor subfamily 3 group B member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04540 ESRRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04541 Esrrb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04542 ESRRB Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esrrb NCBI NCBI:2103