GDF10 - growth differentiation factor 10 Gene

Homo sapiens

Also known as BIP; BMP3B; BMP-3b

Gene ID: 2662 | Gene type: protein coding

About GDF10

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:47,300,197-47,313,577 (from NCBI)

This gene has 1 transcript (splice variant), 261 orthologues and 31 paralogues. Biased expression in lung (RPKM 8.6), fat (RPKM 5.4) and 12 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral Cancer. [provided by RefSeq, Jul 2016]

GDF10 Products(1)

mRNA	Protein	Name
NM_004962.5	NP_004953.1	growth/differentiation factor 10 preproprotein

GDF10 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

growth/differentiation factor 10

bone morphogenetic protein 3B

Recombinant GDF10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7332	BMP-3B/GDF10 Protein, Human (His)	P55107 (Q369-R478)	≥95%

Related Diseases

Diseases

Alias

Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

Van Der Knaap Disease	Leukoencephalopathy With Swelling And Cysts
MLC1	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts
Lvm	Vl
Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1
Megalencephalic Leukoencephalopathy With Subcortical Cysts

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05350	GDF10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GDF10	VGNC	VGNC:72908
Rattus norvegicus	GDF10	RGD	RGD:621512
Canis familiaris	GDF10	VGNC	VGNC:41158
Bos taurus	GDF10	VGNC	VGNC:29299
Felis catus	GDF10	VGNC	VGNC:108137
Mus musculus	GDF10	MGD	MGI:95684
Others	GDF10	NCBI

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