Dab1 - DAB adaptor protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266729

Summary

Enables phosphatidylinositol 3-kinase binding activity. Involved in midgut development; nervous system development; and response to xenobiotic stimulus. Located in several cellular components, including brush border; neuronal cell body; and postsynaptic density. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dab1 Products (2)

mRNA Protein Name
NM_001411819.1 NP_001398748.1 disabled homolog 1
NM_153621.2 NP_705885.1 disabled homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
12882964 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
20368265 RGD
involved in cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
18160654 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
19946030 RGD
involved in neuron migration IDA
IDA: Inferred from direct assay
12882964 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10436054 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
19946030 RGD
located in brush border IDA
IDA: Inferred from direct assay
19946030 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14961563 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disabled homolog 1

  • DAB1, reelin adaptor protein

  • Dab, reelin signal transducer, homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03510 DAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03840 DNAAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09781 OMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19317 Dab1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25808 Dab1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dab1 NCBI NCBI:1600