Hspa4 - heat shock protein family A (Hsp70) member 4 Gene

Also Known as Hsp70; irp94; Hsp110

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266759

About Hspa4

Primary_assembly 10: 37,408,025-37,449,001 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 294 orthologues, 13 paralogues and is associated with 18 phenotypes. Biased expression in Kidney (RPKM 486.9), Adrenal (RPKM 469.5) and 9 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of macromolecule metabolic process; and positive regulation of angiogenesis. Located in cytosol; lipid droplet; and nucleus. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (HSP70) member 4). [provided by Alliance of Genome Resources, Apr 2022]

Hspa4 Products (1)

mRNA Protein Name
NM_153629.1 NP_705893.1 heat shock 70 kDa protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17473852 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17473852 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21561597 RGD
Biological Process GO Annotation Evidence References Source
involved in kidney development IEP
IEP: Inferred from expression pattern
21938673 RGD
involved in negative regulation of apoptotic process IEP
IEP: Inferred from expression pattern
21857080 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17473852 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17473852 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17473852 RGD
involved in positive regulation of angiogenesis IEP
IEP: Inferred from expression pattern
22098710 RGD
involved in regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
17473852 RGD
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
17175194 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa4 Protein Structure

HSPA4_NBD

HSPA4_NBD: cd11737 (1 - 383)

PTZ00121

PTZ00121: cl31754 (498 - 742)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 840 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 4

  • heat shock protein 4

  • heat shock protein family A member 4

  • ischemia responsive 94 kDa protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06428 HSPA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06429 Hspa4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06430 Hspa4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06431 HSPA4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21867 Hspa4l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa4 NCBI NCBI:3308