UQCRQ - ubiquinol-cytochrome c reductase complex III subunit VII Gene

Also Known as QPC; QCR8; QP-C; UQCR7; MC3DN4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27089

About UQCRQ

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,866,642-132,868,847 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 47.2), colon (RPKM 46.6) and 25 other tissues.

Summary

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

UQCRQ Products (1)

mRNA Protein Name
NM_014402.5 NP_055217.2 cytochrome b-c1 complex subunit 8

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRQ Protein Structure

UcrQ

UcrQ: UcrQ family (2 - 81)

  • 0
  • 82 a.a.
Protein Preferred Names Protein Names

cytochrome b-c1 complex subunit 8

  • complex III subunit 8

Related Diseases

Diseases Alias
Mitochondrial Complex Iii Deficiency, Nuclear Type 4

  • Mitochondrial Complex Iii Deficiency Nuclear Type 4

  • MC3DN4

  • Mitochondrial Complex Iv Deficiency, Nuclear Type 3

  • MC4DN3

  • Mitochondrial Complex 4 Deficiency, Nuclear Type 3

  • Mitochondrial Complex Iii Deficiency, Nuclear 4

  • Mitochondrial Complex Iv Deficiency, Nuclear, Type 3
Isolated Complex Iii Deficiency

  • Isolated Coq-Cytochrome C Reductase Deficiency

  • Isolated Coenzyme Q-Cytochrome C Reductase Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex Iii Deficiency

  • Isolated Ubiquinone-Cytochrome C Reductase Deficiency
Mitochondrial Complex Iii Deficiency

  • Complex 3 Mitochondrial Respiratory Chain Deficiency

  • Isolated Coq-Cytochrome C Reductase Deficiency

  • Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Thyroid Hurthle Cell Adenoma

  • Benign Oncocytoma Of The Thyroid

  • Thyroid Gland Oncocytic Adenoma
Otosalpingitis

  • Eustachian Salpingitis

  • Eustachian Tube Salpingitis

  • Rhinosalpingitis

  • Tubotympanitis

  • Eustachian Tube Inflammation

  • Salpingitis Of Ear
Combined Oxidative Phosphorylation Deficiency 22

  • COXPD22

  • Oxidative Phosphorylation Deficiency, Combined, Type 22
Mitochondrial Complex V Deficiency, Mitochondrial Type 1

  • MC5DM1

  • Mitochondrial Complex V Deficiency Mitochondrial Type 1

  • Mitochondrial Complex V Deficiency, Mitochondrial 1

  • Adult-Onset Ataxia And Polyneuropathy

  • Infantile Hypertrophic Cardiomyopathy

  • Mitochondrial Complex 5 Deficiency, Mitochondrial Type 1
Eustachian Tube Disease

  • Eustachian Tube Disorder

  • Auditory Tube Disorder

  • Disease Of Eustachian Tube

  • Eustachian Tube Dysfunction

  • Et- [Eustachian Tube Disorder]

  • Etd - [Eustachian Tube Dysfunction]
Gracile Syndrome

  • Finnish Lethal Neonatal Metabolic Syndrome

  • Growth Retardation, Amino Aciduria, Cholestasis, Iron Overload, Lactic Acidosis, And Early Death

  • Flnms

  • Fellman Syndrome

  • Fellman Disease

  • Finnish Lactic Acidosis With Hepatic Hemosiderosis

  • Growth Restriction-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome

  • Growth Delay-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome

  • Lactic Acidosis, Finnish, With Hepatic Hemosiderosis

  • Growth Retardation, Aminoaciduria, Cholestasis, Iron Overload, Lactic Acidosis And Early Death

  • GRACILE
Non-Suppurative Otitis Media

  • Nonsuppurative Otitis Media
Leigh Syndrome

  • Leigh Disease

  • Infantile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

  • LS

  • Sne

  • Leigh'S Disease

  • Leigh Syndrome Due To Mitochondrial Complex I Deficiency

  • Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

  • Subacute Necrotizing Encephalomyelopathy

  • Necrotizing Encephalopathy Infantile Subacute Of Leigh

  • Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

  • Infantile Necrotizing Encephalomyelopathy

  • Juvenile Subacute Necrotizing Encephalomyelopathy

  • Leigh'S Necrotizing Encephalopathy

  • Subacute Necrotizing Encephalopathy

  • Juvenile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

  • Leigh Syndrome Due To Mitochondrial Complex V Deficiency

  • Encephalopathy, Subacute Necrotizing, Infantile

  • Encephalopathy, Subacute Necrotizing, Juvenile

  • Maternally Inherited Leigh Syndrome

  • Subacute Necrotising Encephalomyelopathy

  • Subacute Necrotising Encephalopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15503 UQCRQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22897 Uqcrq Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29411 Uqcrq Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UQCRQ VGNC VGNC:36697
Rattus norvegicus UQCRQ RGD RGD:1562350
Mus musculus UQCRQ MGD MGI:107807
Canis familiaris UQCRQ VGNC VGNC:48165
Felis catus UQCRQ VGNC VGNC:66850
Macaca mulatta UQCRQ VGNC VGNC:110422
Others UQCRQ NCBI