IL36B - interleukin 36 beta Gene

Also Known as FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27177

About IL36B

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,022,089-113,052,867 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 7 paralogues. Biased expression in skin (RPKM 1.1) and esophagus (RPKM 0.5).

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL36B Products (2)

mRNA Protein Name
NM_014438.5 NP_055253.2 interleukin-36 beta isoform 1
NM_173178.3 NP_775270.1 interleukin-36 beta isoform 2
Protein Preferred Names Protein Names

interleukin-36 beta

  • FIL1 eta

Recombinant IL36B Proteins

Cat. No. Product Name Accession Purity
HY-P71862 IL-36 beta/IL-1F8 Protein, Human (153a.a) Q9NZH7-2 (R5-E157) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72545 IL-36 beta/IL-1F8 Protein, Human Q9NZH7-2 (M1-E157) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74803 IL-36 beta/IL-1F8 Protein, Human (His) Q9NZH7-2 (R5-E157) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74803AF Animal-Free IL-36 beta/IL-1F8 Protein, Human (His) Q9NZH7-2 (R5-E157) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Impetigo Herpetiformis
Psoriasis 14, Pustular

  • Generalized Pustular Psoriasis

  • Gpp

  • Ditra

  • Acrodermatitis Continua Of Hallopeau

  • Palmoplantar Pustulosis

  • PSORS14

  • Interleukin 36 Receptor Antagonist Deficiency

  • Psorp

  • Pustular Psoriasis 14

  • Deficiency Of Il-36r Antagonist

  • Acute Generalised Pustular Psoriasis

  • Deficiency Of The Interleukin-36 Receptor Antagonist

  • Generalized Pustular Psoriasis Of Von Zumbusch

  • Von Zumbusch Psoriasis

  • Deficiency Of Il-36ra

  • Psoriasis, Pustular, Generalized

  • Psoriasis, Pustular, Type 14

  • Pustulosis Of Palms And Soles

  • Acute Generalized Pustular Psoriasis

  • Palmoplantar Pustular Psoriasis

  • Pustulosis Palmaris Et Plantaris

  • Ppp - [Palmoplantar Pustulosis]

  • Pustular Psoriasis Of The Palms And Soles

  • Pustular Bacterid
Miliaria Crystallina
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06760 IL36B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19695 Il36b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26190 Il36b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL36B VGNC VGNC:30157
Mus musculus IL36B MGD MGI:1916927
Macaca mulatta IL36B VGNC VGNC:73603
Rattus norvegicus IL36B RGD RGD:1307847
Canis familiaris IL36B VGNC VGNC:41984
Others IL36B NCBI