Plek2 - pleckstrin 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27260

Summary

Enables phosphatidylinositol-3,4-bisphosphate binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Involved in actin Cytoskeleton reorganization and positive regulation of plasma membrane bounded cell projection assembly. Acts upstream of or within actin Cytoskeleton organization and positive regulation of cell projection organization. Located in plasma membrane. Orthologous to human PLEK2 (pleckstrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Plek2 Products (1)

mRNA Protein Name
NM_013738.3 NP_038766.1 pleckstrin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
11001876 MGI
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
11001876 MGI
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
17008542 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
17008542 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
10419454 MGI
acts upstream of or within positive regulation of cell projection organization IMP
IMP: Inferred from mutant phenotype
10419454 MGI
involved in positive regulation of plasma membrane bounded cell projection assembly IDA
IDA: Inferred from direct assay
17008542 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10548495 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
17008542 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10419454 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10678 PLEK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22732 Plek2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29246 Plek2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plek2 NCBI NCBI:26499