GMFB - glia maturation factor beta Gene

Homo sapiens

Also known as GMF

Gene ID: 2764 | Gene type: protein coding

About GMFB

Cytogenetic location: 14q22.2 Genomic coordinates (GRCh38): 14:54,474,485-54,488,980 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 45.0), colon (RPKM 21.0) and 24 other tissues.

Summary

Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within learning and locomotory behavior. [provided by Alliance of Genome Resources, Apr 2022]

GMFB Products(1)

mRNA	Protein	Name
NM_004124.3	NP_004115.1	glia maturation factor beta

GMFB Protein Structure

Cofilin_ADF

0
100
142 a.a.

Protein Preferred Names

Protein Names

glia maturation factor beta

GMF-beta

Recombinant GMFB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7362	Glia maturation factor beta/GMFB Protein, Human	P60983 (M1-H142)	≥95%
HY-P70387	Glia maturation factor beta/GMFB Protein, Human (His)	P60983 (M1-H142)	≥95%

Related Diseases

Diseases

Alias

Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type	Amcn
Arthrogryposis Multiplex Congenita Neurogenic Type	AMC2
Amc, Neurogenic Type	Neurogenic-Type Arthrogryposis Multiplex Congenita-2
Amc Neurogenic Type	Neurogenic Type Of Amc
Neurogenic Arthrogryposis Multiplex Congenita	Arthrogryposis Multiplex Congenita, Neurogenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05518	GMFB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GMFB	VGNC	VGNC:80964
Macaca mulatta	GMFB	VGNC	VGNC:108300
Canis familiaris	GMFB	VGNC	VGNC:41288
Rattus norvegicus	GMFB	RGD	RGD:70910
Bos taurus	GMFB	VGNC	VGNC:29434
Mus musculus	GMFB	MGD	MGI:1927133
Others	GMFB	NCBI