2. Gene
  3. GRK5 - G protein-coupled receptor kinase 5 Gene

GRK5 - G protein-coupled receptor kinase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GPRK5; FP2025

Gene ID: 2869 | Gene type: protein coding

About GRK5

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,207,571-119,459,745 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 7 paralogues. Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

GRK5 Products(1)

mRNA Protein Name
NM_005308.3 NP_005299.1 G protein-coupled receptor kinase 5

GRK5 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (54 - 170)

Pkinase

Pkinase: Protein kinase domain (187 - 448)

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  • 590 a.a.
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 5

g protein-coupled receptor kinase GRK5

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18991 CCG215022 Inhibitor 98.69% Unkown
HY-103045 CMPD101 Inhibitor 98.95% Unkown
HY-109562A CCG258208 hydrochloride 98.76% Unkown
HY-136561 GRK5-IN-2 99.92% Unkown
HY-47573 CCG273441 Inhibitor 98.67% Unkown
HY-143248 KR-39038 Inhibitor 99.48% Unkown
HY-139690 CCG258747 Inhibitor 99.17% Unkown
HY-108601A (S)-Ro 32-0432 Inhibitor / Unkown
HY-109562 CCG258208 / Unkown
HY-108601 (S)-Ro 32-0432 free base Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-149720 GRL018-21 Inhibitor / Unkown
HY-150021 GRK5-IN-3 Inhibitor / Unkown
HY-150022 GRK5-IN-4 Inhibitor / Unkown
HY-150039 CCG-271423 Inhibitor / Unkown
HY-150040 CCG-273463 Inhibitor / Unkown
HY-RS05816 GRK5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRK5 MGD MGI:109161
Felis catus GRK5 VGNC VGNC:97451
Rattus norvegicus GRK5 RGD RGD:61985
Canis familiaris GRK5 VGNC VGNC:41505
Bos taurus GRK5 VGNC VGNC:29656
Macaca mulatta GRK5 VGNC VGNC:73267