GRK5 - G protein-coupled receptor kinase 5 Gene

Also Known as GPRK5; FP2025

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2869

About GRK5

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,207,571-119,459,745 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 7 paralogues. Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

GRK5 Products (1)

mRNA Protein Name
NM_005308.3 NP_005299.1 G protein-coupled receptor kinase 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-adrenergic receptor kinase activity IMP
IMP: Inferred from mutant phenotype
20038610 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17986524 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
20124405 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
20124405 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22099983 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
14976207 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
22099983 GOA
involved in tachykinin receptor signaling pathway IDA
IDA: Inferred from direct assay
17986524 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14976207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK5 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (54 - 170)

Pkinase

Pkinase: Protein kinase domain (187 - 448)

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  • 500
  • 590 a.a.
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 5

  • g protein-coupled receptor kinase GRK5

GRK5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810884 GRK5 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179707 GRL-03022 Inhibitor / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRK5 MGD MGI:109161
Felis catus GRK5 VGNC VGNC:97451
Rattus norvegicus GRK5 RGD RGD:61985
Canis familiaris GRK5 VGNC VGNC:41505
Bos taurus GRK5 VGNC VGNC:29656
Macaca mulatta GRK5 VGNC VGNC:73267
Others GRK5 NCBI