Serpinf1 - serpin family F member 1 Gene

Also Known as Pedf; Dmrs91

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287526

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to lipid; and short-term memory. Located in several cellular components, including axon hillock; basement membrane; and perinuclear region of cytoplasm. Used to study Alzheimer's disease; middle cerebral artery infarction; and type 2 diabetes mellitus. Biomarker of endometriosis; obesity; portal hypertension; retinal disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including brain edema; eye disease (multiple); leukostasis; non-alcoholic steatohepatitis; and osteogenesis imperfecta type 6. Orthologous to human SERPINF1 (Serpin family F member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpinf1 Products (1)

mRNA Protein Name
NM_177927.2 NP_808788.1 pigment epithelium-derived factor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to cobalt ion IEP
IEP: Inferred from expression pattern
21922517 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
15051476 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19107574 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
15051476 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
17497179 RGD
involved in negative regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
11792807 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21922517 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
23466670 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
23825416 RGD
involved in response to acidic pH IEP
IEP: Inferred from expression pattern
19575033 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
23229538 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
10360224 RGD
involved in response to peptide IDA
IDA: Inferred from direct assay
10423332 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
21738387 RGD
involved in short-term memory IDA
IDA: Inferred from direct assay
17073149 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
10411342 RGD
located in axon hillock IDA
IDA: Inferred from direct assay
10411342 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
15616035 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
19575033 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17653050 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10411342 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10411342 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pigment epithelium-derived factor

  • alpha-2 antiplasmin

  • serine (or cysteine) peptidase inhibitor, clade F, member 1

  • serine (or cysteine) proteinase inhibitor, clade F), member 1

  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

  • sserpi

Recombinant Serpinf1 Proteins

Cat. No. Product Name Accession Purity
HY-P74557 Serpin F1 Protein, Rat (HEK293, His) Q80ZA3/NP_808788.1 (Q20-T418) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12725 SERPINF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18213 Serpinf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24690 Serpinf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpinf1 NCBI NCBI:5176