Fcgr2b - Fc gamma receptor 2B Gene

Also Known as CD32; FCRII; Fcgr2; FcgammaRIIB2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289211

Summary

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to lipopolysaccharide; and negative regulation of neutrophil apoptotic process. Located in cell surface; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2b Products (1)

mRNA Protein Name
NM_175756.3 NP_786932.2 low affinity immunoglobulin gamma Fc region receptor II

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgG binding IDA
IDA: Inferred from direct assay
7590913 RGD
enables immunoglobulin binding IDA
IDA: Inferred from direct assay
18295888 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
23921129 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19106808 RGD
involved in endocytic recycling IDA
IDA: Inferred from direct assay
17680646 RGD
involved in immune complex clearance IDA
IDA: Inferred from direct assay
17680646 RGD
involved in negative regulation of neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
19106808 RGD
involved in positive regulation of response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
23921129 RGD
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
17680646 RGD
involved in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23921129 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
21774811 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
18295888 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
17680646 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low affinity immunoglobulin gamma Fc region receptor II

low affinity immunoglobulin gamma Fc region receptor II-b

  • FC-gamma RII

  • Fc fragment of IgG receptor IIb

  • Fc fragment of IgG, low affinity IIb, receptor

  • Fc gamma receptor IIb

  • Fc receptor, IgG, low affinity IIb

  • igG Fc receptor II beta

Recombinant Fcgr2b Proteins

Cat. No. Product Name Accession Purity
HY-P76235 Fc gamma RIIB/CD32b Protein, Rat (HEK293, His) Q63203 (H32-P212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04829 FCGR2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17922 Fcgr2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24392 Fcgr2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992211 Anti-CD32b/FCGR2B Antibody (2B6) Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fcgr2b NCBI NCBI:2213