TIMM21 - translocase of inner mitochondrial membrane 21 Gene

Also Known as TIM21; HSPC154; C18orf55

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29090

Summary

Involved in mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex IV assembly; and protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in heart (RPKM 23.3), kidney (RPKM 13.3) and 25 other tissues.

TIMM21 Products (1)

mRNA Protein Name
NM_014177.3 NP_054896.2 mitochondrial import inner membrane translocase subunit Tim21 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
23260140 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in mitochondrial cytochrome c oxidase assembly IMP
IMP: Inferred from mutant phenotype
23260140 GOA
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
23260140 GOA
involved in protein import into mitochondrial matrix IMP
IMP: Inferred from mutant phenotype
23260140 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of TIM23 mitochondrial import inner membrane translocase complex IDA
IDA: Inferred from direct assay
23260140 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TIMM21 Q9BVV7 TIMM23 Homo sapiens O14925
Anti Tag CoIP
23260140
Intra
TIMM21 Q9BVV7 MT-CO1 Homo sapiens P00395
Anti Tag CoIP
23260140
Intra
TIMM21 Q9BVV7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
TIMM21 Q9BVV7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
TIMM21 Q9BVV7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14531 TIMM23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14530 TIMM22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown