Aars1 - alanyl-tRNA synthetase 1 Gene

Also Known as Aars

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292023

Summary

Enables several functions, including ATP binding activity; alanine-tRNA Ligase activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N and developmental and epileptic encephalopathy 29. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Aars1 Products (1)

mRNA Protein Name
NM_001100517.1 NP_001093987.1 alanine--tRNA ligase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IPI
IPI: Inferred from physical interaction
2040280 RGD
enables alanine-tRNA ligase activity IDA
IDA: Inferred from direct assay
2040280 RGD
enables amino acid binding IPI
IPI: Inferred from physical interaction
2040280 RGD
enables tRNA binding IPI
IPI: Inferred from physical interaction
2040280 RGD
Biological Process GO Annotation Evidence References Source
involved in alanyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
2040280 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alanine--tRNA ligase, cytoplasmic

  • alaRS

  • alanyl-tRNA synthetase, cytoplasmic

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00028 AARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147908 Adenosine receptor inhibitor 2 Inhibitor 99.08% Unkown
HY-RS17458 Aars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151139 LJ-4517 Antagonist / Unkown
HY-165509 DU172 Ligand / Unkown
HY-RS23915 Aars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aars1 NCBI NCBI:16