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Cat. No.: HY-165509

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DU172

DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC₅₀ of 24.9 nM against A1AR and an IC₅₀ of 0.42 μM against A2AAR.

For research use only. We do not sell to patients.

CAS No.: 321907-03-3
Formula: C₂₄H₃₀FN₅O₅S
Molecular Weight:519.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DU172 Chemical Structure

CAS No.: 321907-03-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC₅₀ of 24.9 nM against A1AR and an IC₅₀ of 0.42 μM against A2AAR^[1]^[2].

All Adenosine Receptor Isoforms :

In Vitro

DU172 (Compound 23a) potently binds to the A₁ adenosine receptor on the cell membrane of DDT₁ MF-2, with an IC₅₀ of 24.9 nM for inhibiting [³H]DPCPX binding^[2].
DU172 binds to the A_2A adenosine receptor on the membrane of PC-12 cells, with an IC₅₀ of 0.42 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 321907-03-3
Molecular Weight 519.59
Formula C₂₄H₃₀FN₅O₅S
SMILES

O=C(NCCCN1C(=O)N(C(=O)C=2NC(=NC21)C3CCCCC3)CCC)C4=CC=C(C=C4)S(=O)(=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Glukhova A, et al. Structure of the Adenosine A₁ Receptor Reveals the Basis for Subtype Selectivity. Cell. 2017;168(5):867-877.e13. [Content Brief]

[2]. Beauglehole AR, et al. Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. J Med Chem. 2000;43(26):4973-4980. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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