Cbr1 - carbonyl reductase 1 Gene

Also Known as Cbr; PG-9-KR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29224

Summary

Enables carbonyl reductase (NADPH) activity. Involved in several processes, including ovulation from ovarian follicle; phylloquinone catabolic process; and prostaglandin catabolic process. Located in microvillus; nucleus; and plasma membrane. Biomarker of chronic kidney disease. Orthologous to human CBR1 (carbonyl reductase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cbr1 Products (1)

mRNA Protein Name
NM_019170.2 NP_062043.1 carbonyl reductase [NADPH] 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbonyl reductase (NADPH) activity IDA
IDA: Inferred from direct assay
7705364 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24882364 RGD
Biological Process GO Annotation Evidence References Source
involved in ovulation from ovarian follicle IEP
IEP: Inferred from expression pattern
10642578 RGD
involved in phylloquinone catabolic process IDA
IDA: Inferred from direct assay
16359670 RGD
involved in prostaglandin catabolic process IDA
IDA: Inferred from direct assay
7705364 RGD
involved in response to estradiol IDA
IDA: Inferred from direct assay
3796215 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
12444039 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12399253 RGD
involved in response to progesterone IDA
IDA: Inferred from direct assay
3796215 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16457595 RGD
involved in steroid catabolic process IDA
IDA: Inferred from direct assay
7705364 RGD
Cellular Component GO Annotation Evidence References Source
located in microvillus IDA
IDA: Inferred from direct assay
16457595 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carbonyl reductase [NADPH] 1

  • 15-hydroxyprostaglandin dehydrogenase

  • 20-beta-hydroxysteroid dehydrogenase

  • Cbr 1

  • NADPH-dependent carbonyl reductase 1

  • alcohol dehydrogenase [NAD(P)+] CBR1

  • prostaglandin 9-ketoreductase

  • prostaglandin-E(2) 9-reductase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155587 Hydroxy-PP Inhibitor 99.66% Unkown
HY-121710 MonoHER Inhibitor 97.02% Unkown
HY-157447 CBR1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbr1 NCBI NCBI:873