CBR1 - carbonyl reductase 1 Gene

Also Known as CBR; hCBR1; PG-9-KR; SDR21C1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 873

About CBR1

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,070,024-36,073,164 (from NCBI)

This gene has 5 transcripts (splice variants), 362 orthologues and 13 paralogues. Broad expression in duodenum (RPKM 163.2), small intestine (RPKM 98.7) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as Quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

CBR1 Products (2)

mRNA Protein Name
NM_001286789.2 NP_001273718.1 carbonyl reductase [NADPH] 1 isoform 2
NM_001757.4 NP_001748.1 carbonyl reductase [NADPH] 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables carbonyl reductase (NADPH) activity IDA
IDA: Inferred from direct assay
1921984 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: Inferred from direct assay
19442656 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
28878267 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in glucocorticoid metabolic process IDA
IDA: Inferred from direct assay
28878267 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
19442656 GOA
involved in vitamin K metabolic process IDA
IDA: Inferred from direct assay
18449627 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
18449627 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBR1 Protein Structure

adh_short

adh_short: short chain dehydrogenase (7 - 146)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

carbonyl reductase [NADPH] 1

  • 15-hydroxyprostaglandin dehydrogenase

Recombinant CBR1 Proteins

Cat. No. Product Name Accession Purity
HY-P72272 CBR1 Protein, Human (P.pastoris, His) P16152 (S2-W277) ≥ 90%, as determined by reducing SDS-PAGE.

CBR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80590 CBR1 Antibody (YA810) WB, ICC/IF Human
HY-P80590A CBR1 Antibody (YA810)(PBS only) WB, ICC/IF Human
HY-P85567 CBR1 Antibody (YA5259) WB, ICC/IF Human

Related Diseases

Diseases Alias
Constipation
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Depersonalization Disorder

  • Neurotic Derealization

  • Depersonalization

  • Depersonalization/Derealization Disorder

  • Depersonalisation-Derealization Syndrome

  • Depersonalisation Disorder

  • Depersonalisation Neurosis

  • Depersonalisation Syndrome

  • Feeling Of Unreality

  • Feels Own Self Is Unreal

  • Neurotic State With Depersonalisation

  • Neurotic State With Depersonalization Episode
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155587 Hydroxy-PP Inhibitor 99.66% Unkown
HY-121710 MonoHER Inhibitor 97.02% Unkown
HY-157447 CBR1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CBR1 RGD RGD:7631561
Macaca mulatta CBR1 VGNC VGNC:80854
Mus musculus CBR1 MGD MGI:88284
Others CBR1 NCBI