2. Gene
  3. Acvr2a - activin A receptor type 2A Gene

Acvr2a - activin A receptor type 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Acvr2; rActR-II

Gene ID: 29263 | Gene type: protein coding

About Acvr2a

Primary_assembly 3: 33,205,523-33,289,968 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues.

Summary

Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development; positive regulation of follicle-stimulating hormone secretion; and response to organic substance. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products(1)

mRNA Protein Name
NM_031571.3 NP_113759.2 activin receptor type-2A precursor

Acvr2a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (203 - 492)

  • 0
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  • 521 a.a.
Protein Preferred Names Protein Names

activin receptor type-2A

ACTR-IIA

activin A receptor, type IIA

activin receptor IIA

activin receptor type IIA

type II activin receptor

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99355 Bimagrumab Inhibitor 99.07% Phase 3
HY-P99590 Sotatercept 99.61% Phase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2a NCBI NCBI:92
Mus musculus Acvr2a NCBI NCBI:11480