Acvr2a - activin A receptor type 2A Gene

Also Known as Acvr2; rActR-II

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29263

About Acvr2a

Primary_assembly 3: 33,205,523-33,289,968 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues.

Summary

Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development; positive regulation of follicle-stimulating hormone secretion; and response to organic substance. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products (1)

mRNA Protein Name
NM_031571.3 NP_113759.2 activin receptor type-2A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables activin binding IDA
IDA: Inferred from direct assay
12385827 RGD
enables inhibin binding IDA
IDA: Inferred from direct assay
12385827 RGD
Biological Process GO Annotation Evidence References Source
involved in SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
12844345 RGD
involved in autophagy IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in cellular response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in positive regulation of follicle-stimulating hormone secretion IMP
IMP: Inferred from mutant phenotype
11861519 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr2a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (203 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
Protein Preferred Names Protein Names

activin receptor type-2A

  • ACTR-IIA

  • activin A receptor, type IIA

  • activin receptor IIA

  • activin receptor type IIA

  • type II activin receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.95% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-117887 Fidrisertib Inhibitor 98.58% Phase 2
HY-157442 GLPG3312 Antagonist 98.63% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99355 Bimagrumab Inhibitor 99.80% Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-185430 HM-279 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2a NCBI NCBI:92