Tjp1 - tight junction protein 1 Gene

Also Known as ZO-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292994

Summary

Enables protein C-terminus binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to lipopolysaccharide. Located in bicellular tight junction; cytoplasm; and gap junction. Biomarker of several diseases, including brain ischemia; cholestasis; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tjp1 Products (1)

mRNA Protein Name
NM_001106266.1 NP_001099736.1 tight junction protein ZO-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12960056 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16617054 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
15980428 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
16567508 RGD
involved in negative regulation of vascular permeability IEP
IEP: Inferred from expression pattern
20137299 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17515855 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17515855 RGD
involved in response to magnetism IEP
IEP: Inferred from expression pattern
20137299 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18360096 RGD
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17899156 RGD
located in cell-cell junction IDA
IDA: Inferred from direct assay
25486565 RGD
located in gap junction IDA
IDA: Inferred from direct assay
29021339 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tight junction protein ZO-1

  • zona occludens 1

  • zona occludens protein 1

  • zonula occludens protein 1

Tjp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tjp1 F1M4A0 Ocln Rattus norvegicus Q6P6T5
Anti Bait CoIP
22106313
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10886 Zifogaptide Modulator 98.97% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20347 Tjp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14553 TJP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26856 Tjp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tjp1 NCBI NCBI:7082