Ocln - occludin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83497

Summary

Predicted to enable protein domain specific binding activity. Involved in cellular response to tumor necrosis factor and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]

Ocln Products (1)

mRNA Protein Name
NM_031329.3 NP_112619.2 occludin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19470647 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21748286 RGD
involved in response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
20501441 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
31116255 RGD
involved in response to interleukin-18 IMP
IMP: Inferred from mutant phenotype
22001439 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22001439 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
22001439 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

occludin

Ocln Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ocln Q6P6T5 Tjp1 Rattus norvegicus F1M4A0
Anti Bait CoIP
19470647
Intra
Ocln Q6P6T5 Ptk2 Rattus norvegicus O35346
Anti Bait CoIP
19470647
Intra
Ocln Q6P6T5 Ptk2 Rattus norvegicus O35346
Anti Bait CoIP
22106313
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09743 OCLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22265 Ocln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28788 Ocln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ocln NCBI NCBI:100506658