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Ptk2 - protein tyrosine kinase 2 Gene

Also Known as FAK; FRNK; p125FAK

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25614

About Ptk2

Primary_assembly 7: 105,126,728-105,331,783 reverse strand.mRatBN7.2:CM026980.1

This gene has 8 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 32 phenotypes. Biased expression in Lung (RPKM 37.3), Kidney (RPKM 29.5) and 9 other tissues.

Summary

Enables several functions, including identical protein binding activity; Integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and nuclear lumen. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 Products (1)

mRNA	Protein	Name
NM_013081.2	NP_037213.1	focal adhesion kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24480479	RGD
enables integrin binding	IPI IPI: Inferred from physical interaction	16935300	RGD
enables phosphatase binding	IDA IDA: Inferred from direct assay	22609523	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	18854312	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12473661	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12912913	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	12782622	RGD
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	12764094	RGD
involved in cellular response to morphine	IEP IEP: Inferred from expression pattern	26821693	RGD
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	17442274	RGD
involved in intracellular chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	16040720	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16825486	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16899713	RGD
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	12133282	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16923336	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12631140	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	12838510	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	12912913	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	12133282	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15208331	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	12764094	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	15537746	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17412802	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	14969714	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	18359002	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15063155	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16249671	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	16195476	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12912913	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17620366	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	17027000	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22973009	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	18194601	RGD
located in nuclear body	IDA IDA: Inferred from direct assay	16373587	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	22973009	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	12124360	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptk2 Protein Structure

FERM_N_2

B41

FERM_C_FAK1

PTKc_FAK

Focal_AT

0
200
400
600
800
1000
1140 a.a.

Protein Preferred Names	Protein Names
focal adhesion kinase 1	FADK 1 PTK2 protein tyrosine kinase 2 focal adhesion kinase-related nonkinase pp125FAK

Ptk2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ptk2	O35346	Ptrh2	Rattus norvegicus	Q5XI86	IF	21383007
Intra	Ptk2	O35346	Ptrh2	Rattus norvegicus	Q5XI86	Anti Bait CoIP	21383007
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	Anti Tag CoIP	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	Pull Down	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	BN-PAGE	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	Solution Sedimentation	24480479
Intra	Ptk2	O35346	Tjp1	Rattus norvegicus	F1M4A0	Anti Bait CoIP	19470647
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	ITC	24480479
Intra	Ptk2	O35346	Pxn	Mus musculus	Q8VI36	IF	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	GMS	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	SPR	24480479
Intra	Ptk2	O35346	Pip5k1c	Mus musculus	O70161-1	IF	12422220
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	FRET	24480479
Intra	Ptk2	O35346	Ptk2	Rattus norvegicus	O35346	SAXS	24480479

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122844B	Ifebemtinib tosylate	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123919	TL13-112	Inhibitor	98.01%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-111546	BI-3663	Inhibitor	99.84%	Unkown
HY-171770	dAurAB5		99.03%	Unkown
HY-124625	BI-4464	Inhibitor	98.64%	Unkown
HY-122582	TL13-12	Degrader	98.16%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-130521	Pomalidomide-amido-PEG3-C2-NH2		99.11%	Unkown
HY-103471	Y11	Activator	98.34%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-130422	Tos-PEG4-t-butyl ester		/	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-RS11399	PTK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11400	Ptk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26981	Ptk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-176198	BI-0319	Degrader	/	Unkown
HY-182478	MDL-27048	Inhibitor	/	Unkown
HY-RS11401	Ptk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183946	NVP-TAC544	Inhibitor	/	Unkown
HY-RS20473	Ptk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptk2	NCBI	NCBI:5747