Itgb3 - integrin subunit beta 3 Gene

Also Known as GPIIIa

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29302

Summary

Contributes to fibrinogen binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of signal transduction. Located in apical plasma membrane and cell surface. Part of Integrin complex. Colocalizes with focal adhesion. Biomarker of Bacterial pneumonia; glomerulonephritis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (Integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Itgb3 Products (1)

mRNA Protein Name
NM_153720.2 NP_714942.1 integrin beta-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to fibrinogen binding IDA
IDA: Inferred from direct assay
11278919 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
1585837 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
21932665 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
12856576 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12242040 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
16528553 RGD
involved in maintenance of postsynaptic specialization structure EXP
EXP: Inferred from Experiment
20935643 RGD
involved in maintenance of postsynaptic specialization structure IDA
IDA: Inferred from direct assay
20935643 RGD
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9585425 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17620283 RGD
involved in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17157995 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19331142 RGD
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
8603604 RGD
involved in positive regulation of cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
17868879 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
10869268 RGD
involved in positive regulation of glomerular mesangial cell proliferation IMP
IMP: Inferred from mutant phenotype
20135641 RGD
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
11705748 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
12606526 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19723557 RGD
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17157995 RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping EXP
EXP: Inferred from Experiment
20935643 RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: Inferred from direct assay
20935643 RGD
involved in regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
7689577 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
12654355 RGD
involved in response to platelet-derived growth factor IEP
IEP: Inferred from expression pattern
21932665 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21426865 RGD
located in cell surface IDA
IDA: Inferred from direct assay
11278919 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
21426865 RGD
is active in glycinergic synapse EXP
EXP: Inferred from Experiment
20935643 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
20935643 RGD
part of integrin complex IDA
IDA: Inferred from direct assay
17157995 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-3

  • integrin beta 3 (Cd61)

  • integrin, beta 3

  • platelet membrane glycoprotein IIIa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175636 ITGB3-IN-1 Inhibitor 98.69% Unkown
HY-RS06966 ITGB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18524 Itgb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06967 ITGB3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25006 Itgb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb3 NCBI NCBI:3690