GSTA1 - glutathione S-transferase alpha 1 Gene

Also Known as GST2; GTH1; GSTA1-1; GST-epsilon

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2938

About GSTA1

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,791,371-52,803,816 (from NCBI)

This gene has 3 transcripts (splice variants), 129 orthologues and 11 paralogues. Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues.

Summary

This gene encodes a member of a family of Enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of Enzymes has a particular role in protecting cells from Reactive Oxygen Species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GSTA1 Products (2)

mRNA Protein Name
NM_001319059.2 NP_001305988.1 glutathione S-transferase A1 isoform 2
NM_145740.5 NP_665683.1 glutathione S-transferase A1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fatty acid binding IPI
IPI: Inferred from physical interaction
16624487 GOA
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
16624487 GOA
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
9084911 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables steroid delta-isomerase activity IDA
IDA: Inferred from direct assay
11152686 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in glutathione derivative biosynthetic process IDA
IDA: Inferred from direct assay
9084911 GOA
acts upstream of or within glutathione metabolic process IDA
IDA: Inferred from direct assay
11851347 GOA
involved in glutathione metabolic process IDA
IDA: Inferred from direct assay
20606271 GOA
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
16624487 GOA
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
9084911 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTA1 Protein Structure

GST_N

GST_N: Glutathione S-transferase, N-terminal domain (6 - 76)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (101 - 192)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase A1

  • 13-hydroperoxyoctadecadienoate peroxidase

Recombinant GSTA1 Proteins

Cat. No. Product Name Accession Purity
HY-P75153 GSTA1 Protein, Human (HEK293, His, solution) P08263 (M1-F222) ≥ 95%, as determined by reducing SDS-PAGE.

GSTA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811249 GSTA1 Antibody WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Ovarian Endodermal Sinus Tumor

  • Endodermal Sinus Tumor Of Ovary

  • Ovarian Yolk Sac Tumor

  • Endodermal Sinus Tumour Of Ovary

  • Ovarian Endodermal Sinus Tumour

  • Ovarian Yolk Sac Tumour
Ovarian Primitive Germ Cell Tumor
Hemorrhagic Cystitis
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N14116 Garlic oil / Phase 4

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16237 Gsta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178372 GSTO1-IN-4 Inhibitor / Unkown
HY-182059 GSTP1-IN-1 / Unkown
HY-RS05872 GSTA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W615446 GSTO1-IN-3 Inhibitor / Unkown
HY-RS25930 Gsta1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GSTA1 RGD RGD:2753
Others GSTA1 NCBI