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Mecp2 - methyl CpG binding protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29386

Summary

Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of hepatocellular carcinoma; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability Lubs type. Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mecp2 Products (1)

mRNA	Protein	Name
NM_022673.2	NP_073164.2	methyl-CpG-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	9038338	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	23688924	RGD
enables double-stranded methylated DNA binding	IDA IDA: Inferred from direct assay	9038338	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	12473678	RGD
enables four-way junction DNA binding	IDA IDA: Inferred from direct assay	16314321	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	23671328	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	23335972	RGD
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	12473678	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	21425435	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17296936	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24636259	RGD
enables unmethylated CpG binding	IDA IDA: Inferred from direct assay	16314321	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to isoquinoline alkaloid	IDA IDA: Inferred from direct assay	22262897	RGD
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	14593183	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	14751287	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	14751287	RGD
involved in epigenetic regulation of gene expression	IEP IEP: Inferred from expression pattern	20735989	RGD
involved in epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20735989	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	14751287	RGD
involved in lung alveolus development	IEP IEP: Inferred from expression pattern	21425435	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9038338	RGD
involved in negative regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	16881068	RGD
involved in negative regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	24636259	RGD
involved in negative regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	24636259	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19217433	RGD
involved in negative regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	27313794	RGD
involved in negative regulation of primary miRNA processing	IMP IMP: Inferred from mutant phenotype	24636259	RGD
involved in negative regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	27313794	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9038338	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24636259	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in olfactory bulb development	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	26140854	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	20697302	RGD
involved in positive regulation of anterograde dense core granule transport	IMP IMP: Inferred from mutant phenotype	22127389	RGD
involved in positive regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	19442733	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	19442733	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	24188180	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24636259	RGD
involved in positive regulation of retrograde dense core granule transport	IMP IMP: Inferred from mutant phenotype	22127389	RGD
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	23015442	RGD
involved in principal sensory nucleus of trigeminal nerve development	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in regulation of action potential firing threshold	IMP IMP: Inferred from mutant phenotype	27313794	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	19442733	RGD
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	19442733	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	26509893	RGD
involved in response to cocaine	IDA IDA: Inferred from direct assay	23688924	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	20711185	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	22109888	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	17148264	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	23246732	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	22109888	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	18614683	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in striatum development	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in thalamus development	IEP IEP: Inferred from expression pattern	12605461	RGD
involved in ventricular cardiac muscle tissue development	IEP IEP: Inferred from expression pattern	20735989	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	9038338	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19442733	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19442733	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12473678	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
methyl-CpG-binding protein 2	meCP-2 protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08276	MECP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176266	KIT-13	Activator	/	Unkown
HY-RS20053	Mecp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26557	Mecp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mecp2	NCBI	NCBI:4204