Flna - filamin A Gene

Also Known as RGD1560614

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 293860

Summary

Enables SMAD binding activity and mu-type Opioid Receptor binding activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and protein localization to bicellular tight junction. Located in several cellular components, including cytoskeleton; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Colocalizes with actin filament. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Apr 2022]

Flna Products (1)

mRNA	Protein	Name
NM_001134599.1	NP_001128071.1	filamin-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	20167606	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15505042	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22948144	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22076441	RGD
involved in establishment of Sertoli cell barrier	IMP IMP: Inferred from mutant phenotype	22872576	RGD
involved in formation of radial glial scaffolds	IMP IMP: Inferred from mutant phenotype	22076441	RGD
involved in mRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20167606	RGD
involved in positive regulation of actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	22872576	RGD
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22076441	RGD
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	22076441	RGD
involved in protein localization to bicellular tight junction	IMP IMP: Inferred from mutant phenotype	22872576	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	20167606	RGD
located in actin filament	IDA IDA: Inferred from direct assay	15661894	RGD
located in apical dendrite	IDA IDA: Inferred from direct assay	22434607	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	22872576	RGD
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	15661894	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	22434607	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26972007	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22434607	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20167606	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	26972007	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
filamin-A	Endothelial actin-binding protein 280) actin binding protein 280 filamin A, alpha filamin, alpha

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Phase
HY-139142B	Simufilam hydrochloride	99.85%	Phase 3
HY-139142	Simufilam	99.78%	Phase 3
HY-139142A	Simufilam dihydrochloride	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04979	FLNA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18476	Flna Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24957	Flna Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flna	NCBI	NCBI:2316