Foxo3 - forkhead box O3 Gene

Also Known as Fkhrl1; Foxo3a

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 294515

Summary

Enables transcription coregulator binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of programmed cell death; and response to glucocorticoid. Located in cytosol; mitochondrion; and nucleus. Biomarker of obesity. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Apr 2022]

Foxo3 Products (1)

mRNA	Protein	Name
NM_001106395.1	NP_001099865.1	forkhead box protein O3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	22292478	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	23661003	RGD
involved in cellular response to corticosterone stimulus	IEP IEP: Inferred from expression pattern	23494228	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	24183892	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	24278276	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	24183892	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	23086522	RGD
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24278276	RGD
involved in positive regulation of hydrogen peroxide-mediated programmed cell death	IMP IMP: Inferred from mutant phenotype	23585551	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	24278276	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	12683947	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	12683947	RGD
involved in response to water-immersion restraint stress	IEP IEP: Inferred from expression pattern	23079979	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	23494228	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22362515	RGD
located in nucleus	IDA IDA: Inferred from direct assay	22362515	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
forkhead box protein O3	forkhead box O3a

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154919	DC-Y13-27	Activator	99.52%	Unkown
HY-176902	NSC126188	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxo3	NCBI	NCBI:2309