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Ddit3 - DNA-damage inducible transcript 3 Gene

Also Known as RM4; CHOP; Chop10; CHOP-10; Gadd153

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29467

Summary

Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of Autophagy in response to ER overload; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]

Ddit3 Products (2)

mRNA	Protein	Name
NM_001109986.1	NP_001103456.1	DNA damage-inducible transcript 3 protein
NM_024134.2	NP_077048.2	DNA damage-inducible transcript 3 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	8657121	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15829559	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8657121	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8657121	RGD
contributes to sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8657121	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in ER overload response	IMP IMP: Inferred from mutant phenotype	11158311	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	23934647	RGD
involved in embryonic organ development	IEP IEP: Inferred from expression pattern	10419986	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	25332219	RGD
involved in negative regulation of CREB transcription factor activity	IDA IDA: Inferred from direct assay	15829559	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8657121	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15829559	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15826945	RGD
involved in positive regulation of autophagy in response to ER overload	IMP IMP: Inferred from mutant phenotype	25772147	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	28694771	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8657121	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11158311	RGD
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	28694771	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	17105900	RGD
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	8657121	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12609979	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	17251432	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	12609979	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	11811998	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20026213	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15921666	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	8657121	RGD
located in nucleus	IDA IDA: Inferred from direct assay	8657121	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA damage-inducible transcript 3 protein	C/EBP homologous protein C/EBP zeta CCAAT/enhancer-binding protein homologous protein DDIT-3 c/EBP-homologous protein 10 growth arrest and DNA-damage-inducible protein GADD153

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03614	DDIT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS18059	Ddit3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24534	Ddit3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddit3	NCBI	NCBI:1649