Slc1a2 - solute carrier family 1 member 2 Gene

Also Known as Glt; Eaat2; Glt-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29482

About Slc1a2

Primary_assembly 3: 89,005,129-89,126,498 forward strand.mRatBN7.2:CM026976.1

This gene has 7 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 9 phenotypes. Restricted expression toward (RPKM 1451.5).

Summary

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 Products (3)

mRNA Protein Name
NM_001035233.2 NP_001030310.2 excitatory amino acid transporter 2 isoform b
NM_001302089.2 NP_001289018.1 excitatory amino acid transporter 2 isoform c
NM_017215.3 NP_058911.2 excitatory amino acid transporter 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate:sodium symporter activity IDA
IDA: Inferred from direct assay
1448170 RGD
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
1448170 RGD
enables high-affinity L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
10899959 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate transmembrane transport IMP
IMP: Inferred from mutant phenotype
10899959 RGD
Cellular Component GO Annotation Evidence References Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
9334410 RGD
located in cell body IDA
IDA: Inferred from direct assay
9334410 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
11896154 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11950769 RGD
part of membrane protein complex IDA
IDA: Inferred from direct assay
9334410 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
1448170 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11896154 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc1a2 Protein Structure

SDF

SDF: pfam00375 (45 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
Protein Preferred Names Protein Names

excitatory amino acid transporter 2

  • glial glutamate transporter GLT1/V3

  • glial glutamate transporter GLT1/V4

  • glutamate transporter 1

  • high affinity glucose transporter

  • sodium-dependent glutamatespartate transporter 2

  • solute carrier family 1 (glial high affinity glutamate transporter), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13051 SLC1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13052 Slc1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13053 Slc1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a2 NCBI NCBI:6506