Myh7 - myosin heavy chain 7 Gene

Also Known as Bmyo; Myhcb; myHC-beta; myHC-slow

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29557

Summary

Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in aging; cellular response to organonitrogen compound; and muscle contraction. Located in Myosin filament and sarcomere. Part of muscle Myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (Myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]

Myh7 Products (1)

mRNA Protein Name
NM_017240.2 NP_058936.1 myosin-7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
15471982 RGD
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
15471982 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3693405 RGD
enables microfilament motor activity IMP
IMP: Inferred from mutant phenotype
15020307 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
3693405 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to 3,3',5-triiodo-L-thyronine IEP
IEP: Inferred from expression pattern
17111039 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
17111039 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
27249171 RGD
involved in muscle contraction IMP
IMP: Inferred from mutant phenotype
15020307 RGD
Cellular Component GO Annotation Evidence References Source
part of muscle myosin complex IDA
IDA: Inferred from direct assay
3693405 RGD
located in myofibril IDA
IDA: Inferred from direct assay
26150528 RGD
located in myosin filament IDA
IDA: Inferred from direct assay
26150528 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
26150528 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-7

  • beta myosin heavy chain

  • myosin heavy chain polypeptide 7 cardiac muscle fetal

  • myosin heavy chain, cardiac muscle, fetal

  • myosin heavy chain, polypeptide 7

  • myosin, heavy chain 7, cardiac muscle, beta

  • myosin, heavy polypeptide 7, cardiac muscle, beta

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08905 MYH7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08906 MYH7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20779 Myh7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27293 Myh7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27903 Myh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh7 NCBI NCBI:4625