Pak6 - p21 (RAC1) activated kinase 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 296078

About Pak6

Primary_assembly 3: 105,638,653-105,672,975 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 260 orthologues, 36 paralogues and is associated with 6 phenotypes. Biased expression in Brain (RPKM 32.9), Kidney (RPKM 23.) and 5 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; protein phosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including BUB1B-PAK6 (BUB1B-PAK6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Pak6 Products (1)

mRNA Protein Name
NM_001106498.1 NP_001099968.1 serine/threonine-protein kinase PAK 6

Pak6 Protein Structure

PBD

PBD: pfam00786 (10 - 66)

STKc_PAK6

STKc_PAK6: cd06659 (384 - 680)

  • 0
  • 200
  • 400
  • 600
  • 681 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 6

  • p21 (CDKN1A)-activated kinase 6

  • p21 protein (Cdc42/Rac)-activated kinase 6

  • p21-activated kinase 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak6 NCBI NCBI:56924