Pak6 - p21 (RAC1) activated kinase 6 Gene

Rattus norvegicus

Gene ID: 296078 | Gene type: protein coding

About Pak6

Primary_assembly 3: 105,638,653-105,672,975 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 260 orthologues, 36 paralogues and is associated with 6 phenotypes. Biased expression in Brain (RPKM 32.9), Kidney (RPKM 23.) and 5 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; protein phosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including BUB1B-PAK6 (BUB1B-PAK6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Pak6 Products(1)

mRNA	Protein	Name
NM_001106498.1	NP_001099968.1	serine/threonine-protein kinase PAK 6

Pak6 Protein Structure

PBD

STKc_PAK6

0
200
400
600
681 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 6

p21 (CDKN1A)-activated kinase 6	p21 protein (Cdc42/Rac)-activated kinase 6
p21-activated kinase 6

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak6	NCBI	NCBI:56924

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