Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

Also Known as PEK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29702

About Eif2ak3

Primary_assembly 4: 102,805,510-102,866,911 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 137.6), Kidney (RPKM 111.4) and 9 other tissues.

Summary

Enables HSP90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak3 Products (1)

mRNA Protein Name
NM_031599.2 NP_113787.1 eukaryotic translation initiation factor 2-alpha kinase 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
12446770 RGD
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
IDA: Inferred from direct assay
9819435 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11781318 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of translation in response to stress IDA
IDA: Inferred from direct assay
9819435 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9819435 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9819435 RGD
involved in response to manganese-induced endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
23934647 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15936177 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Eif2ak3 Protein Structure

Luminal_EIF2AK3

Luminal_EIF2AK3: cd09768 (98 - 411)

PKc_like

PKc_like: cl21453 (578 - 666)

STKc_EIF2AK3_PERK

STKc_EIF2AK3_PERK: cd14048 (867 - 1066)

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  • 1000
  • 1108 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 2-alpha kinase 3

  • PRKR-like endoplasmic reticulum kinase

  • pancreatic eIF2-alpha kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119240 CCT020312 Activator 99.05% Unkown
HY-RS04244 EIF2AK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04245 Eif2ak3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04246 Eif2ak3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2ak3 NCBI NCBI:9451