2. Gene
  3. Scn8a - sodium voltage-gated channel alpha subunit 8 Gene

Scn8a - sodium voltage-gated channel alpha subunit 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29710 | Gene type: protein coding

About Scn8a

Primary_assembly 7: 131,982,480-132,151,292 forward strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 276 orthologues, 26 paralogues and is associated with 30 phenotypes. Biased expression in Brain (RPKM 284.3), Testes (RPKM 17.1) and 2 other tissues.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in nervous system development; neuronal action potential; and sodium ion transport. Located in axon initial segment; node of Ranvier; and plasma membrane. Is integral component of membrane. Part of voltage-gated Sodium Channel complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]

Scn8a Products(1)

mRNA Protein Name
NM_019266.3 NP_062139.2 sodium channel protein type 8 subunit alpha

Scn8a Protein Structure

Ion_trans

Ion_trans: pfam00520 (130 - 420)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (545 - 699)

Ion_trans

Ion_trans: pfam00520 (749 - 962)

Na_trans_assoc

Na_trans_assoc: pfam06512 (988 - 1189)

Ion_trans

Ion_trans: pfam00520 (1194 - 1470)

Na_channel_gate

Na_channel_gate: cd13433 (1462 - 1514)

Ion_trans

Ion_trans: pfam00520 (1519 - 1773)

GPHH

GPHH: cl25190 (1785 - 1832)

IQ

IQ: smart00015 (1891 - 1912)

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  • 1978 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 8 subunit alpha

Na+ channel

PN4

naCh6

peripheral nerve protein type 4

sodium channel 6

sodium channel protein type VIII subunit alpha

sodium channel, voltage gated, type VIII, alpha subunit

sodium channel, voltage-gated, type 8, alpha polypeptide

sodium channel, voltage-gated, type 8, alpha subunit

sodium channel, voltage-gated, type VIII, alpha polypeptide

voltage-gated sodium channel subunit alpha Nav1.6

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148792 Relutrigine Inhibitor 99.13% Unkown
HY-RS12545 SCN8A Human Pre-designed siRNA Set A / Unkown
HY-RS12546 Scn8a Mouse Pre-designed siRNA Set A / Unkown
HY-RS12547 Scn8a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn8a NCBI NCBI:6334