Scn8a - sodium voltage-gated channel alpha subunit 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29710

About Scn8a

Primary_assembly 7: 131,982,480-132,151,292 forward strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 276 orthologues, 26 paralogues and is associated with 30 phenotypes. Biased expression in Brain (RPKM 284.3), Testes (RPKM 17.1) and 2 other tissues.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in nervous system development; neuronal action potential; and sodium ion transport. Located in axon initial segment; node of Ranvier; and plasma membrane. Is integral component of membrane. Part of voltage-gated Sodium Channel complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]

Scn8a Products (1)

mRNA Protein Name
NM_019266.3 NP_062139.2 sodium channel protein type 8 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15282281 RGD
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
9603190 RGD
enables voltage-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
17273863 RGD
Biological Process GO Annotation Evidence References Source
involved in myelination IEP
IEP: Inferred from expression pattern
16652168 RGD
involved in neuronal action potential IDA
IDA: Inferred from direct assay
15917456 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
17273863 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in peripheral nervous system development IEP
IEP: Inferred from expression pattern
16652168 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
9603190 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21118538 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
11724816 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10779552 RGD
located in node of Ranvier IDA
IDA: Inferred from direct assay
16652168 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
10779552 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
10779552 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
10779552 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn8a Protein Structure

Ion_trans

Ion_trans: pfam00520 (130 - 420)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (545 - 699)

Ion_trans

Ion_trans: pfam00520 (749 - 962)

Na_trans_assoc

Na_trans_assoc: pfam06512 (988 - 1189)

Ion_trans

Ion_trans: pfam00520 (1194 - 1470)

Na_channel_gate

Na_channel_gate: cd13433 (1462 - 1514)

Ion_trans

Ion_trans: pfam00520 (1519 - 1773)

GPHH

GPHH: cl25190 (1785 - 1832)

IQ

IQ: smart00015 (1891 - 1912)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1978 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 8 subunit alpha

  • Na+ channel

  • PN4

  • naCh6

  • peripheral nerve protein type 4

  • sodium channel 6

  • sodium channel protein type VIII subunit alpha

  • sodium channel, voltage gated, type VIII, alpha subunit

  • sodium channel, voltage-gated, type 8, alpha polypeptide

  • sodium channel, voltage-gated, type 8, alpha subunit

  • sodium channel, voltage-gated, type VIII, alpha polypeptide

  • voltage-gated sodium channel subunit alpha Nav1.6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-148792 Relutrigine Inhibitor 99.33% Phase 3
HY-147423 Zandatrigine Inhibitor 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12545 SCN8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12546 Scn8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12547 Scn8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn8a NCBI NCBI:6334