UBN1 - ubinuclein 1 Gene

Homo sapiens

Also known as VT; VT4

Gene ID: 29855 | Gene type: protein coding

About UBN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,847,481-4,882,401 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 1 paralogue. Broad expression in testis (RPKM 22.1), bone marrow (RPKM 13.0) and 25 other tissues.

Summary

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

UBN1 Products(2)

mRNA	Protein	Name
NM_001079514.3	NP_001072982.1	ubinuclein-1 isoform a
NM_001288656.1	NP_001275585.1	ubinuclein-1 isoform b

UBN1 Protein Structure

HUN

UBN_AB

0
200
400
600
800
1000
1134 a.a.

Protein Preferred Names

Protein Names

ubinuclein-1

HIRA-binding protein

Related Diseases

Diseases

Alias

Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3	CPVT3
Cvpt3	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15379	UBN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBN1	VGNC	VGNC:36610
Rattus norvegicus	UBN1	RGD	RGD:1311582
Felis catus	UBN1	VGNC	VGNC:66778
Macaca mulatta	UBN1	VGNC	VGNC:78703
Canis familiaris	UBN1	VGNC	VGNC:48081
Mus musculus	UBN1	MGD	MGI:1891307