UBN1 - ubinuclein 1 Gene

Also Known as VT; VT4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29855

About UBN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,847,481-4,882,401 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 1 paralogue. Broad expression in testis (RPKM 22.1), bone marrow (RPKM 13.0) and 25 other tissues.

Summary

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

UBN1 Products (2)

mRNA Protein Name
NM_001079514.3 NP_001072982.1 ubinuclein-1 isoform a
NM_001288656.1 NP_001275585.1 ubinuclein-1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18823282 GOA
Biological Process GO Annotation Evidence References Source
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10725330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBN1 Protein Structure

HUN

HUN: HPC2 and ubinuclein domain (115 - 169)

UBN_AB

UBN_AB: Ubinuclein conserved middle domain (353 - 575)

  • 0
  • 200
  • 400
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  • 1000
  • 1134 a.a.
Protein Preferred Names Protein Names

ubinuclein-1

  • HIRA-binding protein

UBN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBN1 Q9NPG3 HIRA Homo sapiens P54198
Anti Bait CoIP
19029251
Cross: Cross-species interaction Intra: Intraspecies interaction

UBN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810123 UBN-1 Antibody (YA9467) WB, IP human

Related Diseases

Diseases Alias
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

  • Catecholaminergic Polymorphic Ventricular Tachycardia 3

  • CPVT3

  • Cvpt3

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15379 UBN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22352 Ubn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28874 Ubn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBN1 VGNC VGNC:36610
Rattus norvegicus UBN1 RGD RGD:1311582
Felis catus UBN1 VGNC VGNC:66778
Macaca mulatta UBN1 VGNC VGNC:78703
Canis familiaris UBN1 VGNC VGNC:48081
Mus musculus UBN1 MGD MGI:1891307
Others UBN1 NCBI