Pum2 - pumilio RNA-binding family member 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298874

Summary

Predicted to enable mRNA 3'-UTR binding activity and miRNA binding activity. Predicted to be involved in positive regulation of RIG-I signaling pathway; regulation of chromosome segregation; and regulation of gene expression. Predicted to act upstream of or within stress granule assembly. Predicted to be located in cytoplasmic stress granule; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Pum2 Products (1)

mRNA Protein Name
NM_001106715.1 NP_001100185.1 pumilio homolog 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
31606248 RGD
involved in positive regulation of sprouting of injured axon IMP
IMP: Inferred from mutant phenotype
31606248 RGD
involved in regulation of intracellular mRNA localization IMP
IMP: Inferred from mutant phenotype
31606248 RGD
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
20133610 RGD
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
20133610 RGD
involved in regulation of translation IMP
IMP: Inferred from mutant phenotype
31606248 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16775137 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
31606248 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
16775137 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pumilio homolog 2

  • pumilio 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11462 PUM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22291 Pum2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28814 Pum2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pum2 NCBI NCBI:23369