Dlst - dihydrolipoamide S-succinyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299201

Summary

Enables chaperone binding activity; dihydrolipoyllysine-residue succinyltransferase activity; and heat shock protein binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Located in mitochondrion and plasma membrane. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlst Products (1)

mRNA Protein Name
NM_001006981.2 NP_001006982.2 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dihydrolipoyllysine-residue succinyltransferase activity IDA
IDA: Inferred from direct assay
9405249 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
9811814 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
9811814 RGD
Biological Process GO Annotation Evidence References Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
3571202 RGD
involved in NADH metabolic process IDA
IDA: Inferred from direct assay
9405249 RGD
Cellular Component GO Annotation Evidence References Source
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
3571202 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

  • 2-oxoglutarate dehydrogenase complex component E2

  • E2

  • E2K

  • OGDC-E2

  • dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

  • dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03811 DLST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18924 Dlst Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25414 Dlst Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlst NCBI NCBI:1743