Hsp90ab1 - heat shock protein 90 alpha family class B member 1 Gene

Also Known as HSPC2; Hspcb; HSP90B; HSP90-BETA

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 301252

Summary

Enables nucleotide binding activity; sulfonylurea receptor binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; positive regulation of protein import into nucleus; and regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and ooplasm. Biomarker of muscular atrophy; pancreatitis; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90ab1 Products (1)

mRNA	Protein	Name
NM_001004082.3	NP_001004082.3	heat shock protein HSP 90-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables CTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables UTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables dATP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	18218611	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18644871	RGD
enables protein folding chaperone	IMP IMP: Inferred from mutant phenotype	17517623	RGD
enables sulfonylurea receptor binding	IPI IPI: Inferred from physical interaction	20427569	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20427569	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	10617604	RGD
involved in chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	17517623	RGD
involved in negative regulation of complement-dependent cytotoxicity	IMP IMP: Inferred from mutant phenotype	16135098	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18443201	RGD
involved in negative regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	17517623	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	20980790	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20980790	RGD
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	18443201	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	22860061	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	15497505	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	24478030	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in cell surface	IDA IDA: Inferred from direct assay	19948165	RGD
located in inclusion body	IDA IDA: Inferred from direct assay	18445155	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18644871	RGD
located in ooplasm	IDA IDA: Inferred from direct assay	19022436	RGD
part of protein folding chaperone complex	IMP IMP: Inferred from mutant phenotype	17517623	RGD
located in sperm head plasma membrane	IDA IDA: Inferred from direct assay	24478030	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
heat shock protein HSP 90-beta	HSP 84 HSP84 heat shock 84 kDa heat shock 90kDa protein 1, beta heat shock protein 90 alpha (cytosolic), class B member 1 heat shock protein 90kDa alpha (cytosolic), class B member 1 heat shock protein 90kDa alpha family class B member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-123035	Gamendazole	Inhibitor	99.44%	Unkown
HY-RS06418	HSP90AB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N7521	Procyanidin C2		/	Unkown
HY-RS18017	Hsp90ab1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24490	Hsp90ab1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hsp90ab1	NCBI	NCBI:3326