2. Gene
  3. HAS3 - hyaluronan synthase 3 Gene

HAS3 - hyaluronan synthase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3038 | Gene type: protein coding

About HAS3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,083,484-69,118,719 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in urinary bladder (RPKM 19.2), lung (RPKM 12.8) and 24 other tissues.

Summary

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

HAS3 Products(3)

mRNA Protein Name
NM_001199280.2 NP_001186209.1 hyaluronan synthase 3 isoform a
NM_005329.3 NP_005320.2 hyaluronan synthase 3 isoform a
NM_138612.3 NP_619515.1 hyaluronan synthase 3 isoform b

HAS3 Protein Structure

Glyco_tranf_2_3

Glyco_tranf_2_3: Glycosyltransferase like family 2 (86 - 359)

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  • 553 a.a.
Protein Preferred Names Protein Names

hyaluronan synthase 3

HA synthase 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143894 FLT3-IN-11 Inhibitor / Unkown
HY-RS06008 HAS3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HAS3 RGD RGD:628656
Canis familiaris HAS3 VGNC VGNC:41601
Mus musculus HAS3 MGD MGI:109599
Macaca mulatta HAS3 VGNC VGNC:73348
Felis catus HAS3 VGNC VGNC:67537
Bos taurus HAS3 VGNC VGNC:29756