HAS3 - hyaluronan synthase 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3038

About HAS3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,083,484-69,118,719 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in urinary bladder (RPKM 19.2), lung (RPKM 12.8) and 24 other tissues.

Summary

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by Other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

HAS3 Products (3)

mRNA Protein Name
NM_001199280.2 NP_001186209.1 hyaluronan synthase 3 isoform a
NM_005329.3 NP_005320.2 hyaluronan synthase 3 isoform a
NM_138612.3 NP_619515.1 hyaluronan synthase 3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hyaluronan synthase activity IDA
IDA: Inferred from direct assay
16900089 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25795779 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20507985 GOA
Biological Process GO Annotation Evidence References Source
involved in hyaluronan biosynthetic process IDA
IDA: Inferred from direct assay
16900089 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16900089 GOA
involved in positive regulation of hyaluranon cable assembly IDA
IDA: Inferred from direct assay
16900089 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25795779 GOA
located in hyaluranon cable IDA
IDA: Inferred from direct assay
16900089 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25795779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAS3 Protein Structure

Glyco_tranf_2_3

Glyco_tranf_2_3: Glycosyltransferase like family 2 (86 - 359)

  • 0
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  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

hyaluronan synthase 3

  • HA synthase 3

HAS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAS3 O00219 HAS1 Homo sapiens Q92839
FRET
25795779
Intra
HAS3 O00219 HAS1 Homo sapiens Q92839
Anti Tag CoIP
25795779
Intra
HAS3 O00219 HAS2 Homo sapiens Q92819
FRET
25795779
Intra
HAS3 O00219 HAS3 Homo sapiens O00219
Anti Tag CoIP
25795779
Intra
HAS3 O00219 HAS3 Homo sapiens O00219
Confocal
25795779
Intra
HAS3 O00219 HAS3 Homo sapiens O00219
FRET
25795779
Cross: Cross-species interaction Intra: Intraspecies interaction

HAS3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83786 HAS3 Antibody (YA3483) IHC-P, FC, ELISA Human
HY-P83786A HAS3 Antibody (YA3483)(PBS only) IHC-P, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06008 HAS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143894 FLT3-IN-11 Inhibitor / Unkown
HY-P2937A DNA polymerase, NeoApollonia Thermophilus / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HAS3 RGD RGD:628656
Canis familiaris HAS3 VGNC VGNC:41601
Mus musculus HAS3 MGD MGI:109599
Macaca mulatta HAS3 VGNC VGNC:73348
Felis catus HAS3 VGNC VGNC:67537
Bos taurus HAS3 VGNC VGNC:29756
Others HAS3 NCBI