Tiam1 - TIAM Rac1 associated GEF 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304109

Summary

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; generation of neurons; and regulation of MAPK cascade. Located in several cellular components, including axon; postsynaptic density; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Apr 2022]

Tiam1 Products (1)

mRNA Protein Name
NM_001100558.2 NP_001094028.1 T-lymphoma invasion and metastasis-inducing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
11264310 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12446731 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16801538 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
18930714 RGD
involved in cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
22564263 RGD
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
20333299 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
16203995 RGD
involved in positive regulation of Schwann cell chemotaxis IMP
IMP: Inferred from mutant phenotype
16203995 RGD
involved in positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
11264310 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
24123220 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
16474385 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20333299 RGD
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
18930714 RGD
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22564263 RGD
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
18930714 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
15721239 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
15721239 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
15721239 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
15721239 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
23745104 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
11264310 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16474385 RGD
is active in extrinsic component of postsynaptic density membrane IDA
IDA: Inferred from direct assay
15721239 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15721239 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15721239 RGD
located in main axon IDA
IDA: Inferred from direct assay
11264310 RGD
located in microtubule IDA
IDA: Inferred from direct assay
11264310 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11264310 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
12446731 RGD
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
23300879 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-lymphoma invasion and metastasis-inducing protein 1

  • T-cell lymphoma invasion and metastasis 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16659 EHT 1864 Inhibitor 99.85% Unkown
HY-104064 1A-116 99.72% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-P1382A Rac1 Inhibitor W56 TFA Inhibitor 99.92% Unkown
HY-171977 UTKO1 Inhibitor / Unkown
HY-P1382 Rac1 Inhibitor W56 Inhibitor / Unkown
HY-RS14515 TIAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18300 Tiam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24778 Tiam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tiam1 NCBI NCBI:7074