Bcl11a - BCL11 transcription factor A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 305589

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to L-glutamate; negative regulation of branching morphogenesis of a nerve; and negative regulation of dendrite development. Located in cytoplasm; nucleus; and postsynaptic density. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BAF chromatin remodeling complex subunit BCL11A). [provided by Alliance of Genome Resources, Apr 2022]

Bcl11a Products (1)

mRNA Protein Name
NM_001191683.1 NP_001178612.1 B-cell lymphoma/leukemia 11A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20623620 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-glutamate IEP
IEP: Inferred from expression pattern
20534004 RGD
involved in negative regulation of branching morphogenesis of a nerve IMP
IMP: Inferred from mutant phenotype
19616629 RGD
involved in negative regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
19616629 RGD
involved in negative regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
19616629 RGD
involved in negative regulation of neuron remodeling IMP
IMP: Inferred from mutant phenotype
19616629 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19616629 RGD
Cellular Component GO Annotation Evidence References Source
is active in postsynapse IDA
IDA: Inferred from direct assay
17455301 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell lymphoma/leukemia 11A

  • B-cell CLL/lymphoma 11A (zinc finger protein)

  • BAF chromatin remodeling complex subunit BCL11A

  • BCL11A, BAF complex component

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152775 RK-701 Inhibitor 98.01% Unkown
HY-147099 dTAG-47-NEG Control 98.93% Unkown
HY-RS01413 BCL11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20529 Bcl11a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27038 Bcl11a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl11a NCBI NCBI:53335